Table 1 HLTF alterations in lung adenocarcinoma and squamous cell carcinoma
Adenocarcinoma (n = 578) Number of cases, n (%) | Squamous cell carcinoma (n = 504) Number of cases, n (%) | P-value (Fisher test) | |
|---|---|---|---|
Mutation | 13 (2.2%) | 8 (1.5%) | 0.5110 |
Copy number alterations | |||
Homozygous deletion | 1 (0.1%) | 1 (0.2%) | 1.00 |
Heterozygosity loss | 115 (22.3%) | 15 (2.9%) | < 0.0001 |
Diploid | 268 (52.0%) | 68 (13.5%) | < 0.0001 |
Gain | 120 (23.3%) | 286 (57.0%) | < 0.0001 |
High level of amplification | 11 (2.1%) | 131 (26.1%) | < 0.0001 |
No data | 63 | 3 | |
mRNA expression level | |||
High expression | 43 (7.5%) | 141 (28.6%) | < 0.0001 |
Low expression | 0 (0.0%) | 6 (1.2%) | 0.0101 |
Total number of altered cases | |||
266 (46.0%) | 438 (83.0%) | < 0.0001 | |