Fig. 2

HLTF mutations in NSCLC. a. Lung adenocarcinoma. b. Lung squamous cell carcinoma. Mutation data were retrieved from TCGA and COSMIC databases. HLTF protein is depicted as a grey line with its functional domains: DNA binding domain (DBD, orange box), HIRAN (brown box), SNF2 (blue box), Helicase/ATPase I-III (yellow boxes), zinc finger RING (green box). Under the protein is a scale showing the amino-acid size. Mutation are depicted by colored dots (missense: green; spliced or stop mutation: red) with their position and the residue change