Variable | Model |
MTHFR rs1801133 Genotype | OR (95% CI)^{a} | p ^{b} |
MTHFR rs1801131 Genotype | OR (95% CI) | p |
ERCC2 rs1799793 Genotype | OR (95% CI) | p |
ERCC2 rs13181 Genotype | OR (95% CI) | p |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age (Years) (> 40 /≤40) | C/C (54/19)^{c} | 1 | A/A (53/30) | 1 | G/G (46/30) | 1 | A/A (53/27) | 1 | |||||
He | T/C (27/27) | 2.84 (1.35–6.00) | 0.006 | C/A (34/25) | 1.30 (0.66–2.57) | 0.45 | G/A (35/15) | 0.66 (0.31–1.40) | 0.28 | C/A (27/23) | 1.67 (0.81–3.45) | 0.16 | |
Ho | T/T (14/10) | 2.03 (0.77–5.33) | 0.15 | C/C (8/1) | 0.47 (0.16–1.36) | 0.16 | A/A (14/11) | 1.20 (0.48–3.00) | 0.69 | C/C (15/6) | 0.79 (0.27–2.25) | 0.37 | |
D | C/C (54/19) | 1 | A/A (53/30) | 1 | G/G (46/30) | 1 | A/A (53/27) | 1 | |||||
T/C-T/T (41/37) | 2.56 (1.29–5.09) | 0.006 | C/A-C/C (42/26) | 1.09 (0.56–2.12) | 0.79 | G/A-A/A (49/26) | 0.81 (0.42–1.58) | 0.54 | C/A-C/C (42/29) | 1.36 (0.70–2.63) | 0.37 | ||
R | C/C-T/C (81/46) | 1 | A/A-C/A (87/55) | 1 | G/G-G/A (81/45) | 1 | A/A-C/A (80/50) | 1 | |||||
T/T (14/10) | 1.26 (0.52–3.06) | 0.61 | C/C (8/1) | 0.20 (0.02–1.62) | 0.07 | A/A (14/11) | 1.41 (0.59–3.37) | 0.44 | C/C (15/6) | 0.64 (0.23–1.76) | 0.38 | ||
OD | C/C-T/T (68/29) | 1 | A/A-C/C (61/31) | 1 | G/G-A/A (60/41) | 1 | A/A-C/C (68/33) | 1 | |||||
T/C (27/27) | 2.34 (1.18–4.67) | 0.015 | C/A (34/25) | 1.45 (0.74–2.84) | 0.28 | G/A (35/15) | 0.63 (0.30–1.29) | 0.2 | C/A (27/23) | 1.76 (0.88–3.52) | 0.11 | ||
A | – | 1.62 (1.03–2.55) | 0.036 | – | 0.89 (0.51–1.53) | 0.67 | – | 1.00 (0.64–1.55) | 0.98 | – | 1.05 (0.66–1.66) | 0.84 | |
Family history (Sporadic/Familial) | C/C (51/22) | 1 | A/A (41/42) | 1 | G/G (39/37) | 1 | A/A (40/40) | 1 | |||||
He | T/C (18/36) | 4.64 (2.18–9.86) | 6.8.10 ^{−5} | C/A (28/31) | 1.08 (0.55–2.11) | 0.82 | G/A (29/21) | 0.76 (0.37–1.57) | 0.46 | C/A (28/22) | 0.79 (0.39–1.60) | 0.5 | |
Ho | T/T (8/16) | 4.64 (1.73–12.42) | 0.002 | C/C (8/1) | 0.12 (0.01–1.02) | 0.05 | A/A (9/16) | 1.87 (0.74–4.76) | 0.18 | C/C (9/12) | 1.33 (0.51–3.51) | 0.56 | |
D | C/C (51/22) | 1 | A/A (41/42) | 1 | G/G (39/37) | 1 | A/A (40/40) | 1 | |||||
T/C-T/T (26/52) | 4.64 (2.33–9.21) | < 10 ^{−4} | C/A-C/C (36/32) | 0.87 (0.46–1.65) | 0.66 | G/A-A/A (38/37) | 1.03 (0.54–1.94) | 0.94 | C/A-C/C (37/34) | 0.92 (0.48–1.74) | 0.8 | ||
R | C/C-T/C (69/58) | 1 | A/A-C/A (69/73) | 1 | G/G-G/A (68/58) | 1 | A/A-C/A (68/62) | 1 | |||||
T/T (8/16) | 2.38 (0.95–5.96) | 0.057 | C/C (8/1) | 0.12 (0.01–0.97) | 0.01 | A/A (9/16) | 2.08 (0.86–5.07) | 0.1 | C/C (9/12) | 1.46 (0.58–3.71) | 0.42 | ||
OD | C/C-T/T (59/38) | 1 | A/A-C/C (49/43) | 1 | G/G-A/A (48/53) | 1 | A/A-C/C (49/52) | 1 | |||||
T/C (18/36) | 3.11 (1.55–6.24) | 0.001 | C/A (28/31) | 1.26 (0.66–2.43) | 0.49 | G/A (29/21) | 0.66 (0.33–1.30) | 0.22 | C/A (28/22) | 0.74 (0.37–1.46) | 0.39 | ||
A | – | 2.61 (1.60–4.25) | < 10 ^{−4} | – | 0.71 (0.42–1.21) | 0.2 | – | 1.21 (0.79–1.86) | 0.38 | – | 1.05 (0.67–1.63) | 0.84 | |
ER Status (Positive/ Negative) | C/C (52/18) | 1 | A/A (62/16) | 1 | G/G (48/22) | 1 | A/A (53/21) | 1 | |||||
He | T/C (35/14) | 1.16 (0.51–2.62) | 0.73 | C/A (39/18) | 1.79 (0.82–3.92) | 0.14 | G/A (38/12) | 0.69 (0.30–1.57) | 0.37 | C/A (36/12) | 0.84 (0.37–1.92) | 0.68 | |
Ho | T/T (20/4) | 0.58 (0.17–1.92) | 0.37 | C/C (6/2) | 1.29 (0.24–7.01) | 0.8 | A/A (21/2) | 0.21 (0.04–0.96) | 0.045 | C/C (18/3) | 0.42 (0.11–1.58) | 0.2 | |
D | C/C (52/18) | 1 | A/A (62/16) | 1 | G/G (48/22) | 1 | A/A (53/21) | 1 | |||||
T/C-T/T (55/18) | 0.95 (0.44–2.01) | 0.88 | C/A-C/C (45/20) | 1.72 (0.80–3.69) | 0.16 | G/A-A/A (59/14) | 0.52 (0.24–1.12) | 0.091 | C/A-C/C (54/15) | 0.70 (0.33–1.50) | 0.36 | ||
R | C/C-T/C (87/32) | 1 | A/A-C/A (101/34) | 1 | G/G-G/A (86/34) | 1 | A/A-C/A (89/33) | 1 | |||||
T/T (20/4) | 0.54 (0.17–1.71) | 0.28 | C/C (6/2) | 0.99 (0.19–5.14) | 0.99 | A/A (21/2) | 0.24 (0.05–1.08) | 0.03 | C/C (18/3) | 0.45 (0.12–1.63) | 0.19 | ||
OD | C/C-T/T (72/22) | 1 | A/A-C/C (68/18) | 1 | G/G-A/A (69/24) | 1 | A/A-C/C (71/24) | 1 | |||||
T/C (35/14) | 1.31 (0.60–2.86) | 0.5 | C/A (39/18) | 1.74 (0.81–3.74) | 0.15 | G/A (38/12) | 0.91 (0.41–2.02) | 0.81 | C/A (36/12) | 0.99 (0.44–2.20) | 0.97 | ||
A | – | 0.85 (0.50–1.42) | 0.53 | – | 1.43 (0.78–2.65) | 0.25 | – | 0.54 (0.30–0.96) | 0.028 | – | 0.71 (0.41–1.23) | 0.21 | |
PR Status (Positive/Negative) | C/C (46/23) | 1 | A/A (49/25) | 1 | G/G (40/27) | 1 | A/A (48/23) | 1 | |||||
He | T/C (27/18) | 1.33 (0.61–2.90) | 0.47 | C/A (36/19) | 1.03 (0.50–2.16) | 0.93 | G/A (30/17) | 0.84 (0.39–1.81) | 0.66 | C/A (25/20) | 1.67 (0.77–3.61) | 0.19 | |
Ho | T/T (16/7) | 0.88 (0.32–2.43) | 0.8 | C/C (4/4) | 1.96 (0.45–8.50) | 0.4 | A/A (19/4) | 0.31 (0.09–1.02) | 0.05 | C/C (16/5) | 0.81 (0.46–1.41) | 0.45 | |
D | C/C (46/23) | 1 | A/A (49/25) | 1 | G/G (40/27) | 1 | A/A (48/23) | 1 | |||||
T/C-T/T (43/25) | 1.16 (0.58–2.35) | 0.67 | C/A-C/C (40/23) | 1.13 (0.56–2.28) | 0.74 | G/A-A/A (49/21) | 0.63 (0.31–1.29) | 0.21 | C/A-C/C (41/25) | 1.27 (0.63–2.57) | 0.5 | ||
R | C/C-T/C (73/41) | 1 | A/A-C/A (85/44) | 1 | G/G-G/A (70/44) | 1 | A/A-C/A (73/43) | 1 | |||||
T/T (16/7) | 0.78 (0.30–2.05) | 0.61 | C/C (4/4) | 1.93 (0.46–8.10) | 0.37 | A/A (19/4) | 0.33 (0.11–1.05) | 0.04 | C/C (16/5) | 0.53 (0.18–1.55) | 0.23 | ||
OD | C/C-T/T (62/30) | 1 | A/A-C/C (53/29) | 1 | G/G-A/A (59/31) | 1 | A/A-C/C (64/28) | 1 | |||||
T/C (27/18) | 1.38 (0.66–2.88) | 0.4 | C/A (36/19) | 0.96 (0.47–1.98) | 0.92 | G/A (30/17) | 1.08 (0.52–2.25) | 0.84 | C/A (25/20) | 1.83 (0.88–3.82) | 0.11 | ||
A | – | 1.01 (0.63–1.61) | 0.98 | – | 1.20 (0.68–2.14) | 0.53 | – | 0.63 (0.38–1.04) | 0.06 | – | 0.97 (0.60–1.57) | 0.91 | |
Tumor size (T1 / ≥ T3) | C/C (10/14) | 1 | A/A (10/14) | 1 | G/G (12/16) | 1 | A/A (15/11) | 1 | |||||
He | T/C (11/10) | 0.65 (0.20–2.11) | 0.47 | C/A (13/12) | 0.66 (0.21–2.04) | 0.47 | G/A (8/8) | 0.75 (0.22–2.57) | 0.65 | C/A (5/15) | 4.09 (1.14–14.7) | 0.03 | |
Ho | T/T (3/4) | 0.95 (0.17–5.23) | 0.95 | C/C (1/2) | 1.43 (0.11–18.0) | 0.78 | A/A (4/4) | 0.75 (0.16–3.62) | 0.72 | C/C (4/2) | 0.68 (0.11–4.41) | 0.68 | |
D | C/C (10/14) | 1 | A/A (10/14) | 1 | G/G (12/16) | 1 | A/A (15/11) | 1 | |||||
T/C-T/T (14/14) | 0.71 (0.24–2.14) | 0.55 | C/A-C/C (14/14) | 0.71 (0.24–2.14) | 0.55 | G/A-A/A (12/12) | 0.75 (0.25–2.24) | 0.61 | C/A-C/C (9/17) | 2.58 (0.84–7.91) | 0.09 | ||
R | C/C-T/C (21/24) | 1 | A/A-C/A (23/26) | 1 | G/G-G/A (20/24) | 1 | A/A-C/A (20/26) | 1 | |||||
T/T (3/4) | 1.17 (0.23–5.82) | 0.85 | C/C (1/2) | 1.77 (0.15–20.8) | 0.64 | A/A (4/4) | 0.83 (0.18–3.76) | 0.81 | C/C (4/2) | 0.38 (0.06–2.31) | 0.28 | ||
OD | C/C-T/T (13/18) | 1 | A/A-C/C (11/16) | 1 | G/G-A/A (16/20) | 1 | A/A-C/C (19/13) | 1 | |||||
T/C (11/10) | 0.66 (0.22–2.00) | 0.46 | C/A (13/12) | 0.63 (0.21–1.9) | 0.42 | G/A (8/8) | 0.80 (0.25–2.6) | 0.71 | C/A (5/15) | 4.38 (1.28–15.1) | 0.01 | ||
A | – | 0.87 (0.40–1.91) | 0.74 | – | 0.86 (0.34–2.15) | 0.75 | – | 0.84 (0.40–1.76) | 0.64 | – | 1.35 (0.60–3.03) | 0.47 |