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Table 3 Association of MTHFR-rs1801133, rs1801131, ERCC2-rs1799793 and rs13181 SNPs with age at diagnosis, family history, ER status, PR status and tumor size of breast cancer patients

From: Significant association between ERCC2 and MTHR polymorphisms and breast cancer susceptibility in Moroccan population: genotype and haplotype analysis in a case-control study

Variable Model MTHFR
rs1801133
Genotype
OR (95% CI)a p b MTHFR
rs1801131
Genotype
OR (95% CI) p ERCC2
rs1799793
Genotype
OR (95% CI) p ERCC2
rs13181
Genotype
OR (95% CI) p
Age
(Years)
(> 40 /≤40)
  C/C (54/19)c 1   A/A (53/30) 1   G/G (46/30) 1   A/A (53/27) 1  
He T/C (27/27) 2.84 (1.35–6.00) 0.006 C/A (34/25) 1.30 (0.66–2.57) 0.45 G/A (35/15) 0.66 (0.31–1.40) 0.28 C/A (27/23) 1.67 (0.81–3.45) 0.16
Ho T/T (14/10) 2.03 (0.77–5.33) 0.15 C/C (8/1) 0.47 (0.16–1.36) 0.16 A/A (14/11) 1.20 (0.48–3.00) 0.69 C/C (15/6) 0.79 (0.27–2.25) 0.37
D C/C (54/19) 1   A/A (53/30) 1   G/G (46/30) 1   A/A (53/27) 1  
  T/C-T/T (41/37) 2.56 (1.29–5.09) 0.006 C/A-C/C (42/26) 1.09 (0.56–2.12) 0.79 G/A-A/A (49/26) 0.81 (0.42–1.58) 0.54 C/A-C/C (42/29) 1.36 (0.70–2.63) 0.37
R C/C-T/C (81/46) 1   A/A-C/A (87/55) 1   G/G-G/A (81/45) 1   A/A-C/A (80/50) 1  
  T/T (14/10) 1.26 (0.52–3.06) 0.61 C/C (8/1) 0.20 (0.02–1.62) 0.07 A/A (14/11) 1.41 (0.59–3.37) 0.44 C/C (15/6) 0.64 (0.23–1.76) 0.38
OD C/C-T/T (68/29) 1   A/A-C/C (61/31) 1   G/G-A/A (60/41) 1   A/A-C/C (68/33) 1  
  T/C (27/27) 2.34 (1.18–4.67) 0.015 C/A (34/25) 1.45 (0.74–2.84) 0.28 G/A (35/15) 0.63 (0.30–1.29) 0.2 C/A (27/23) 1.76 (0.88–3.52) 0.11
A 1.62 (1.03–2.55) 0.036 0.89 (0.51–1.53) 0.67 1.00 (0.64–1.55) 0.98 1.05 (0.66–1.66) 0.84
Family history
(Sporadic/Familial)
  C/C (51/22) 1   A/A (41/42) 1   G/G (39/37) 1   A/A (40/40) 1  
He T/C (18/36) 4.64 (2.18–9.86) 6.8.10 −5 C/A (28/31) 1.08 (0.55–2.11) 0.82 G/A (29/21) 0.76 (0.37–1.57) 0.46 C/A (28/22) 0.79 (0.39–1.60) 0.5
Ho T/T (8/16) 4.64 (1.73–12.42) 0.002 C/C (8/1) 0.12 (0.01–1.02) 0.05 A/A (9/16) 1.87 (0.74–4.76) 0.18 C/C (9/12) 1.33 (0.51–3.51) 0.56
D C/C (51/22) 1   A/A (41/42) 1   G/G (39/37) 1   A/A (40/40) 1  
  T/C-T/T (26/52) 4.64 (2.33–9.21) < 10 −4 C/A-C/C (36/32) 0.87 (0.46–1.65) 0.66 G/A-A/A (38/37) 1.03 (0.54–1.94) 0.94 C/A-C/C (37/34) 0.92 (0.48–1.74) 0.8
R C/C-T/C (69/58) 1   A/A-C/A (69/73) 1   G/G-G/A (68/58) 1   A/A-C/A (68/62) 1  
  T/T (8/16) 2.38 (0.95–5.96) 0.057 C/C (8/1) 0.12 (0.01–0.97) 0.01 A/A (9/16) 2.08 (0.86–5.07) 0.1 C/C (9/12) 1.46 (0.58–3.71) 0.42
OD C/C-T/T (59/38) 1   A/A-C/C (49/43) 1   G/G-A/A (48/53) 1   A/A-C/C (49/52) 1  
  T/C (18/36) 3.11 (1.55–6.24) 0.001 C/A (28/31) 1.26 (0.66–2.43) 0.49 G/A (29/21) 0.66 (0.33–1.30) 0.22 C/A (28/22) 0.74 (0.37–1.46) 0.39
A 2.61 (1.60–4.25) < 10 −4 0.71 (0.42–1.21) 0.2 1.21 (0.79–1.86) 0.38 1.05 (0.67–1.63) 0.84
ER
Status
(Positive/ Negative)
  C/C (52/18) 1   A/A (62/16) 1   G/G (48/22) 1   A/A (53/21) 1  
He T/C (35/14) 1.16 (0.51–2.62) 0.73 C/A (39/18) 1.79 (0.82–3.92) 0.14 G/A (38/12) 0.69 (0.30–1.57) 0.37 C/A (36/12) 0.84 (0.37–1.92) 0.68
Ho T/T (20/4) 0.58 (0.17–1.92) 0.37 C/C (6/2) 1.29 (0.24–7.01) 0.8 A/A (21/2) 0.21 (0.04–0.96) 0.045 C/C (18/3) 0.42 (0.11–1.58) 0.2
D C/C (52/18) 1   A/A (62/16) 1   G/G (48/22) 1   A/A (53/21) 1  
  T/C-T/T (55/18) 0.95 (0.44–2.01) 0.88 C/A-C/C (45/20) 1.72 (0.80–3.69) 0.16 G/A-A/A (59/14) 0.52 (0.24–1.12) 0.091 C/A-C/C (54/15) 0.70 (0.33–1.50) 0.36
R C/C-T/C (87/32) 1   A/A-C/A (101/34) 1   G/G-G/A (86/34) 1   A/A-C/A (89/33) 1  
  T/T (20/4) 0.54 (0.17–1.71) 0.28 C/C (6/2) 0.99 (0.19–5.14) 0.99 A/A (21/2) 0.24 (0.05–1.08) 0.03 C/C (18/3) 0.45 (0.12–1.63) 0.19
OD C/C-T/T (72/22) 1   A/A-C/C (68/18) 1   G/G-A/A (69/24) 1   A/A-C/C (71/24) 1  
  T/C (35/14) 1.31 (0.60–2.86) 0.5 C/A (39/18) 1.74 (0.81–3.74) 0.15 G/A (38/12) 0.91 (0.41–2.02) 0.81 C/A (36/12) 0.99 (0.44–2.20) 0.97
A 0.85 (0.50–1.42) 0.53 1.43 (0.78–2.65) 0.25 0.54 (0.30–0.96) 0.028 0.71 (0.41–1.23) 0.21
PR
Status
(Positive/Negative)
  C/C (46/23) 1   A/A (49/25) 1   G/G (40/27) 1   A/A (48/23) 1  
He T/C (27/18) 1.33 (0.61–2.90) 0.47 C/A (36/19) 1.03 (0.50–2.16) 0.93 G/A (30/17) 0.84 (0.39–1.81) 0.66 C/A (25/20) 1.67 (0.77–3.61) 0.19
Ho T/T (16/7) 0.88 (0.32–2.43) 0.8 C/C (4/4) 1.96 (0.45–8.50) 0.4 A/A (19/4) 0.31 (0.09–1.02) 0.05 C/C (16/5) 0.81 (0.46–1.41) 0.45
D C/C (46/23) 1   A/A (49/25) 1   G/G (40/27) 1   A/A (48/23) 1  
  T/C-T/T (43/25) 1.16 (0.58–2.35) 0.67 C/A-C/C (40/23) 1.13 (0.56–2.28) 0.74 G/A-A/A (49/21) 0.63 (0.31–1.29) 0.21 C/A-C/C (41/25) 1.27 (0.63–2.57) 0.5
R C/C-T/C (73/41) 1   A/A-C/A (85/44) 1   G/G-G/A (70/44) 1   A/A-C/A (73/43) 1  
  T/T (16/7) 0.78 (0.30–2.05) 0.61 C/C (4/4) 1.93 (0.46–8.10) 0.37 A/A (19/4) 0.33 (0.11–1.05) 0.04 C/C (16/5) 0.53 (0.18–1.55) 0.23
OD C/C-T/T (62/30) 1   A/A-C/C (53/29) 1   G/G-A/A (59/31) 1   A/A-C/C (64/28) 1  
  T/C (27/18) 1.38 (0.66–2.88) 0.4 C/A (36/19) 0.96 (0.47–1.98) 0.92 G/A (30/17) 1.08 (0.52–2.25) 0.84 C/A (25/20) 1.83 (0.88–3.82) 0.11
A 1.01 (0.63–1.61) 0.98 1.20 (0.68–2.14) 0.53 0.63 (0.38–1.04) 0.06 0.97 (0.60–1.57) 0.91
Tumor
size
(T1 / ≥ T3)
  C/C (10/14) 1   A/A (10/14) 1   G/G (12/16) 1   A/A (15/11) 1  
He T/C (11/10) 0.65 (0.20–2.11) 0.47 C/A (13/12) 0.66 (0.21–2.04) 0.47 G/A (8/8) 0.75 (0.22–2.57) 0.65 C/A (5/15) 4.09 (1.14–14.7) 0.03
Ho T/T (3/4) 0.95 (0.17–5.23) 0.95 C/C (1/2) 1.43 (0.11–18.0) 0.78 A/A (4/4) 0.75 (0.16–3.62) 0.72 C/C (4/2) 0.68 (0.11–4.41) 0.68
D C/C (10/14) 1   A/A (10/14) 1   G/G (12/16) 1   A/A (15/11) 1  
  T/C-T/T (14/14) 0.71 (0.24–2.14) 0.55 C/A-C/C (14/14) 0.71 (0.24–2.14) 0.55 G/A-A/A (12/12) 0.75 (0.25–2.24) 0.61 C/A-C/C (9/17) 2.58 (0.84–7.91) 0.09
R C/C-T/C (21/24) 1   A/A-C/A (23/26) 1   G/G-G/A (20/24) 1   A/A-C/A (20/26) 1  
  T/T (3/4) 1.17 (0.23–5.82) 0.85 C/C (1/2) 1.77 (0.15–20.8) 0.64 A/A (4/4) 0.83 (0.18–3.76) 0.81 C/C (4/2) 0.38 (0.06–2.31) 0.28
OD C/C-T/T (13/18) 1   A/A-C/C (11/16) 1   G/G-A/A (16/20) 1   A/A-C/C (19/13) 1  
  T/C (11/10) 0.66 (0.22–2.00) 0.46 C/A (13/12) 0.63 (0.21–1.9) 0.42 G/A (8/8) 0.80 (0.25–2.6) 0.71 C/A (5/15) 4.38 (1.28–15.1) 0.01
A 0.87 (0.40–1.91) 0.74 0.86 (0.34–2.15) 0.75 0.84 (0.40–1.76) 0.64 1.35 (0.60–3.03) 0.47
  1. aOR (Odds ratio) and 95% CI (confidence interval)
  2. bbold values are statistically significant (p < 0.05)
  3. cnumber of individuals, ER estrogen receptor, PR progesterone receptor, He Heterozygote, Ho Homozygote, D Dominant, R Recessive, OD Overdominant, A Log-additive
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