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Table 4 Meta-regression circRNA associated with tumor type, sample size (> 50), and endogenous reference

From: CircRNAs as biomarkers of cancer: a meta-analysis

Meta-Regression (Inverse Variance weights)

Var

Coeff.

Std. Err.

p-value

RDOR

[95%CI]

Cte.

5.625

1.6550

0.0048

S

0.098

0.1198

0.4297

HCC

−0.810

0.3463

0.0359

0.44

(0.21;0.94)

GC

−0.402

0.2869

0.1844

0.67

(0.36;1.24)

size

−0.741

0.5329

0.1876

0.48

(0.15;1.51)

ref

−0.186

0.5345

0.7341

0.83

(0.26;2.64)

  1. Tau-squared estimate = 0.0749 (convergence is achieved after 6 iterations)
  2. Restricted Maximum Likelihood estimation (REML)
  3. No. studies = 19
  4. Filter OFF
  5. Add 1/2 to all cells of the studies with zero