CircRNAs as biomarkers of cancer: a meta-analysis

Wang, Miao; Yang, Yuxi; Xu, Jian; Bai, Wen; Ren, Xueli; Wu, Huijian

doi:10.1186/s12885-018-4213-0

BMC Cancer

Table 1 Characteristics of the included studies

From: CircRNAs as biomarkers of cancer: a meta-analysis

	First author	Year	Ethnicity	Sample size		Cancer	Specimen	Method	Dignostic power				CircRNA
	First author	Year	Ethnicity	Control	Case	Cancer	Specimen	Method	Sen	Spe	AUC	Cutoff value	CircRNA
1	Yao Z¹	2017	Asian	102	102	hepatocellular carcinoma	tissue	qRT-PCR	0.822	0.724	0.834	–	circZKSCAN1
2	Fu L²	2017	Asian	102	102	hepatocellular carcinoma	tissue	qRT-PCR	0.716	0.815	0.848	–	hsa_circ_0004018
3	Qin M³	2016	Asian	89	89	hepatocellular carcinoma	tissue	qRT-PCR	0.81	0.69	0.63	0.0007855	hsa_circ_0001649
4	Shang X.C.⁴	2016	Asian	30	30	hepatocellular carcinoma	tissue	qRT-PCR	0.833	0.9	0.94	0.000586	hsa_circ_0005075
5	Fu L⁵	2017	Asian	107	107	hepatocellular carcinoma	tissue	qRT-PCR	0.449	0.868	0.7	12.24	hsa_circ_0003570
6	Shao YF⁶	2017	Asian	311	311	gastric cancer	tissue	qRT-PCR	0.646	0.698	0.72	9.125	hsa_circ_0000705
7	Lu R⁷	2017	Asian	96	96	gastric cancer	tissue	qRT-PCR	0.6	0.81	0.74	8.17	hsa_circ_0006633
8	Li P⁸	2015	Asian	101	101	gastric cancer	tissue	qRT-PCR	0.81	0.62	0.73	12.9	hsa_circ_002059
9	Li P⁹	2017	Asian	101	101	gastric cancer	tissue	qRT-PCR	0.88	0.56	0.82	12.9	hsa_circ_0000096
10	Li W.H.¹⁰	2017	Asian	76	76	gastric cancer	tissue	qRT-PCR	0.711	0.816	0.834	0.2269225	hsa_circ_00001649
11	Chen S¹¹	2017	Asian	104	104	gastric cancer	tissue	qRT-PCR	0.721	0.683	0.75	6.83	hsa_circ_0000190
12	Tian M¹²	2017	Asian	108	108	gastric cancer	tissue	qRT-PCR	0.852	0.565	0.75	12.31	hsa_circ_0003159
13	Shao Y¹³	201,702	Asian	96	96	gastric cancer	tissue	qRT-PCR	0.5938	0.8125	0.696	12.14	hsa_circ_0014717
14	Shao Y¹⁴	201,704	Asian	96	96	gastric cancer	tissue	qRT-PCR	0.678	0.857	0.792	9.53	hsa_circ_0001895
15	Wang XN¹⁵	2015	Asian	31	31	colorectal cancer	tissue	qRT-PCR	0.68	0.73	0.788	6.04	hsa_circ_001988
16	Zhu X¹⁶	2017	Asian	49	49	lung adenocarcinoma	tissue	qRT-PCR	0.755	0.796	0.815	0.00101	hsa_circ_0013958
17	LuL1¹⁷	2017	Asian	51	51	breast cancer	tissue	qRT-PCR	0.65	0.69	0.71	14.84	hsa_circ_006054
18	Lu L2¹⁷	2017	Asian	51	51	breast cancer	tissue	qRT-PCR	0.69	0.71	0.78	8.95	hsa_circ_100219
19	Lu L3¹⁷	2017	Asian	51	51	breast cancer	tissue	qRT-PCR	0.63	0.63	0.64	14.24	hsa_circ_406697

Sen, sensitivity, Spe specificity, AUC area under the ROC curve

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ISSN: 1471-2407

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