Neoadjuvant chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in locally advanced nasopharyngeal carcinoma

Table 3 Main result; overall survival, distant metastasis free survival, loco-regional relapse free survival of the study

Event	NAC-CCRT^a, n (%) vs CCRT-AC^b, n (%)	p-value
Event	Hazard Ratio (95% confidence interval)	p-value
Overall survival
Dead	21 (27%) vs 35 (19%)	0.187
Univariable analysis	1.68 (0.98–2.90)	0.059
Multivariable analysis^c	0.83 (0.45–1.56)	0.571
Distant metastasis free survival
Distant metastasis	13 (16%) vs 30 (16%)	1.000
Univariable analysis	1.26 (0.66–2.42)	0.483
Multivariable analysis^c	0.79 (0.37–1.72)	0.557
Loco-regional relapse free survival
Loco-regional failure	19 (24%) vs 18 (10%)	0.003
Univariable analysis	2.88 (1.51–5.50)	0.001
Multivariable analysis^c	2.18 (0.98–4.87)	0.057

^aNAC-CCRT: neoadjuvant chemotherapy followed by concurrent chemo-radiotherapy
^bCCRT-AC: concurrent chemo-radiotherapy followed by adjuvant chemotherapy
^cAdjusted factors: gender, age, histology type, AJCC staging, complete of radiation treatment

ISSN: 1471-2407