ORR 3/6 months (%) | DCR 3/6 months (%) | Median PFS (months) | Median OS (months) | 1-year OS (%) | |
---|---|---|---|---|---|
All patients (N = 385) | |||||
Overall | 5.7/3.6 | 30.9/17.9 | 3.5 | 7.1 | 30.6 |
Age (years) | |||||
65–69 | 4.5/1.8 | 25.5/12.7 | 3.3 | 7.0 | 26.6 |
70–74 | 4.3/2.9 | 27.1/18.6 | 3.4 | 6.6 | 29.8 |
75–79 | 7.4/6.4 | 42.6/23.4 | 5.0 | 7.9 | 37.2 |
≥ 80 | 10.8/5.4 | 32.4/16.2 | 2.9 | 6.0 | 25.6 |
< 75a (n = 250) | 4.4/2.4 | 26.4/16.0 | 3.3 | 6.8 | 28.3 |
≥ 75a (n = 131) | 8.4/6.1 | 39.7/21.4 | 4.0 | 7.8 | 34 |
ECOG PS | |||||
0 | 6.3/3.1 | 28.1/17.2 | 3.3 | 8.4 | 37.6 |
1 | 6.2/3.3 | 31.4/16.7 | 3.5 | 6.3 | 29.9 |
≥ 2 | 4.2/5.3 | 33.7/23.2 | 3.7 | 7.3 | 29.1 |
Gender | |||||
Male | 5.8/2.7 | 31.8/16.7 | 3.4 | 6.3 | 25.4 |
Female | 5.5/5.5 | 29.1/20.5 | 4.1 | 8.1 | 41.8 |
Post-hoc analysis: Squamous cell histology (n = 86) | |||||
Overall | 8.1/1.2 | 34.9/18.6 | 3.5 | 8.6 | 32.4 |
Age (years) | |||||
< 75 (n = 55) | 5.5/1.8 | 29.1/18.2 | 3.5 | 9.5 | 33.1 |
≥ 75 (n = 30) | 13.3/0 | 43.3/16.7 | 3.6 | 7.8 | 29.1 |
ECOG PS | |||||
0 (n = 12) | 8.3/0 | 50.0/16.7 | 4.6 | 8.7 | 31.4 |
1 (n = 44) | 11.4/0 | 34.1/20.5 | 3.7 | 11.2 | 43.3 |
≥ 2 (n = 27) | 3.7/3.7 | 33.3/18.5 | 3.5 | 7.3 | 19.2 |
Gender | |||||
Male (n = 66) | 6.1/1.5 | 33.3/16.7 | 3.5 | 8.6 | 28.7 |
Female (n = 20) | 15.0/0 | 40.0/25.0 | 4.4 | 9.5 | 44.5 |
Post-hoc analysis: Non-squamous EGFR wild-type (n = 91) | |||||
Overall | 3.3/2.2 | 20.9/11.0 | 3.1 | 5.5 | 28.8 |
Age (years) | |||||
< 75 (n = 60) | 1.7/0 | 20.0/8.3 | 3.1 | 5.2 | 22.3 |
≥ 75 (n = 30) | 6.7/6.7 | 23.3/16.7 | 3.2 | 7.9 | 41.7 |
ECOG PS | |||||
0 (n = 18) | 5.6/0 | 22.5/5.6 | 2.2 | 7.0 | 30.9 |
1 (n = 50) | 2.0/2.0 | 20.0/10.0 | 2.6 | 5.5 | 23.7 |
≥ 2 (n = 18) | 0/5.6 | 22.2/22.2 | 4.2 | 6.8 | 39.2 |
Gender | |||||
Male (n = 54) | 1.9/0 | 18.5/5.6 | 2.1 | 4.7 | 16.2 |
Female (n = 37) | 5.4/5.4 | 24.3/18.9 | 5.0 | 9.3 | 47.9 |