Table 2 Characteristics and methodological quality of studies

Andre [14]

97

Prospective

FOLFOX3 or FOLFOX4 (85 mg/m² as a 2 h infusion day1, repeated every 2 weeks)

Argyriou [17]

170

Prospective

FOLFOX4 (Oxaliplatin: 85 mg/m² as a 2 h infusion on day1, repeated every 2 weeks)

Argyriou [32]

150

Prospective

FOLFOX/XELOX (OX dose) = NR

Davidov [38]

26

Prospective

FOLFOX (Oxaliplatin: 85 mg/m² as a 2 h infusion on day1, repeated every two weeks).

Diaz-Rubio [11]

25

Prospective

Oxaliplatin (130 mg/m² as a 2 hour infusion on day1, repeated every 3 weeks)

Land [36]

395/2492

Prospective

FOLFOX (Oxaliplatin: 85 mg/m² IV infusion on day 1 of week 1, 3 and 5 of each 8 week cycle for three cycles)

Levi [15]

93

Prospective

FOLFOX (25 mg/m²/day infusion for 5 days, repeated every 3 weeks)

Pfeiffer [29]

70

Prospective

XELOX (Oxaliplatin: 130 mg/m² as a 30 min infusion on day1, repeated every 3 weeks)

Ravaioli [33]

45

Prospective

FOLFOX (Oxaliplatin: 130 mg/m² as a 2 h infusion day1, repeated every 3 weeks)

Rothenberg [8]

463

Prospective

Oxaliplatin (85 mg/m² as a 2 h infusion on day1, repeated every 2 weeks) and FOLFOX (85 mg/m² as a 2 h infusion on day1, repeated every 2 weeks)

Schmoll [37]

1864

Prospective

XELOX (Oxaliplatin: 130 mg/m² as a 2 h infusion on day1, repeated every 3 weeks)

Shields [34]

48

Prospective

XELOX (Oxaliplatin: 130 mg/m² as a 2 h infusion on day1, repeated every 3 week)

Sorbye [35]

85

Prospective

FOLFOX (Oxaliplatin:85 mg/m² as a 2 h infusion day1, repeated every 2 weeks)

Storey [25]

188

Retrospective

XELOX (Oxaliplatin: 130 mg/m² 2 h infusion on day 1, repeated every 3 weeks)