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Table 1 Sample description

From: Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project

Variable

Category

Cases (%)

Controls (%)

p

Age at recruitment

< 45 years

214 (19)

234 (18)

< 0.001

45–54 years

317 (28)

282 (21)

 

55–64 years

296 (26)

290 (22)

 

65–74 years

180 (16)

313 (24)

 

≥ 75 years

132 (12)

203 (15)

 

Educational level

Unfinished primary

162 (14)

246 (19)

0.02

Primary studies

391 (34)

405 (31)

 

Secondarystudies

366 (32)

405 (31)

 

High education

220 (19)

266 (20)

 

Parity

Nulliparous

254 (22)

242 (18)

0.007

1

207 (18)

200 (15)

 

2

445 (39)

516 (39)

 

≥ 3

233 (21)

364 (28)

 

Age at menarche

≤ 12 years

436 (38)

487 (37)

0.46

> 12 years

703 (62)

835 (63)

 

Menopausal status

Premenopausal

657 (59)

889 (67)

< 0.001

Postmenopausal

464 (41)

433 (33)

 

Age at menopause

< 50 years

329 (47)

445 (50)

0.18

≥ 50 years

378 (53)

447 (50)

 

Age at first delivery

< 20 years

70 (8)

70 (7)

0.50

20–24 years

247 (28)

286 (28)

 

25–29 years

329 (37)

410 (40)

 

30–34 years

163 (19)

187 (18)

 

≥ 35 years

69 (8)

64 (6)

 

Tobacco use

Non- smoker

607 (53)

792 (60)

0.001

Former smoker

304 (27)

274 (21)

 

Current smoker

228 (20)

256 (19)

 

Body Mass Index (kg/m2)

< 18.5

15 (1)

26 (2)

0.34

18.5–24.9

527 (46)

638 (48)

 

25.0–29.9

387 (34)

414 (31)

 

≥ 30.0

210 (18)

244 (18)

 

Family history of breast cancer

No

764 (67)

1097 (83)

< 0.001

First-degree relative

167 (14)

121 (9)

 

Second-degree relative

24 (2)

14 (1)

 

Other relative

178 (16)

89 (7)

 

Hormonal contraceptive

No

628 (55)

725 (55)

0.88

Yes

511 (45)

597 (45)

 

Hormone replacement therapy

No

1021 (90)

1177 (89)

0.70

Yes

83 (7)

100 (8)