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Fig. 1 | BMC Cancer

Fig. 1

From: CD31 and VEGF are prognostic biomarkers in early-stage, but not in late-stage, laryngeal squamous cell carcinoma

Fig. 1

Immunohistochemical staining and analysis. Immunohistochemical staining of VEGF (a) and CD31 (b) was evaluated. The immune reactive score (IRS) of VEGF was calculated as intensity of the staining reaction, evaluated by three independent observers. VEGF was scored as absent (−), weak (+), medium (++), and strong (+++) (Magnification = 200×) and categorized in low and high. Low includes −/+ and high includes ++/+++. CD31 was scored by absolute vessel counting per visual field (b). The median of the counted CD31-positive vessels was 7.3 per visual field (c) and was used as a cut-off to categorize patients into low (< 7) vs high (≥7)

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BMC Cancer

ISSN: 1471-2407

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