Diagnostic and prognostic implications of ribosomal protein transcript expression patterns in human cancers

BMC Cancer

Table 1 Recurring patterns of RPT expression in tumors across cancer cohorts

Primary Difference	Co-regulated RPTs		Observations
Primary Difference	Lower expression	Higher Expression	Cohort	Cluster
Low RPL3	RPL5, RPL10, RPL17, RPL22, RPL26, RPS23	RPL28, RPL35, RPL36, RPL38, RPLP2	THCA^a	1
			GBMLGG	3, 4
			LIHC	2, 3
			KIRC	3
			THYM	2
			PRAD	2, 3
			PAAD	1
			PCPG	1
			DLBC	2
High RPL8 and RPL30	RPL10, RPL13A, RPL19, RPL21, RPL34, RPL37A, RPL4, UBA52, RPL5, RPS11, RPS12, RPS13, RPS17, RPS27A, RPS8, RPS9	RPL36A, RPL7, RPS20	BRCA	3
			LIHC	3
			PRAD	2
			LUNG	1
			SKCM	2
			HNSC	2
High RPS4X	RPL13, RPL23, RPL37, RPL8, RPLP1, RPS16, RPS2	RPS3A, RPL17	PRAD	1
			KIRC	1
			THCA	1, 2
			STAD	2
			LAML	1
			CESC	2
High RPL13	RPL10, RPL10A, RPL26, RPL3, RPL35A, RPL41, RPL5, RPL7, RPL7A, RPS12, RPS13, RPS14, RPS15A, RPS18, RPS23, RPS27, RPS3, RPS3A, RPS4X, RPS5	RPL12, RPL13, RPL18, RPL24, RPL27A, RPL28, RPL32, RPL35, RPL36, RPL37, RPL38, RPL39, RPLP1, RPLP2, RPS15, RPS17, RPS19, RPS20, RPS24, FAU, RPS4Y1, RPS9	PRAD	3
			UCEC	3
			KIRC	3

Four recurring patterns of expression distinguishing tumor clusters from one another were observed in multiple clusters across cancer cohorts, as shown in Figs. 2 and 3a. For each pattern, the most significant and defining RPT expression difference is listed under “primary difference.” Other significant RPT expression differences associated with these patterns are listed under “co-regulated RPTs.” “Low” and “high” expression is defined relative to other tumors within a cancer cohort. Clusters with the described pattern are listed under “observations”
^aWhile tumors in this cluster had relatively lower expression of RPL3, other RPTs were not co-regulated in the same manner

ISSN: 1471-2407