Fig. 3

Volcano plots of relative RPT expression in tumor clusters associated with survival. a. Volcano plots comparing RPT relative expression between tumor clusters were generated, as in Fig. 2, for the remaining seven cancer cohorts which possessed tumor sub-clustering by t-SNE. Note that for the sake of clarity, clusters 5 and 6 are excluded from the LUNG cohort plot. These clusters correlated near perfectly with amplification and highly significant up-regulation of RPS3 and RPS16, respectively (Table 2). b. Patient survival by t-SNE cluster. Of the 19 cancer cohorts with sub-clustering of RPT expression patterns by t-SNE, seven possessed clusters that correlated with survival. Significance was determined with log-rank and Wilcoxon rank sum tests where appropriate, using all survival data available, including any data points beyond what are displayed in the survival curves