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Fig. 4 | BMC Cancer

Fig. 4

From: Sepsis increases perioperative metastases in a murine model

Fig. 4

Prometastatic effects of sepsis are reversed with perioperative NK cell activation. a Lung metastases are reduced in polyI:C treated animals. Lung metastases were quantified in untreated animals (No Sx, n = 4) and following laparotomy (Lap + Sepsis, n = 4) without or with perioperative antibiotic treatment administered subcutaneously (Abx, Imipenem 0.5 mg, n = 4), preoperative polyI:C treatment (PolyI:C,150 μg/200 μL PBS, n = 4), and a combination of antibiotic and polyI:C treatment (Lap + Sepsis + Abx + PolyI:C, n = 5). b Preoperative PolyI:C restores NK cell cytotoxicity. Chromium release killing assay of YAC-1 tumour target cells by DX5+ NK cells isolated from animals undergoing treatments as above. Effector (DX5+ NK cells) to target (Yac1) (E:T) ratios of 6:1, 12:1, 25:1, and 50:1 are shown (n = 3 for each treatment group and each E:T ratio). Error bars represent ± SEM

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