Table 3 Univariate and multivariate analysis of variables correlated with metastasis-free survival
From: The prognostic significance of topoisomerase II alpha protein in early stage luminal breast cancer
Variable | Univariate | Multivariate | |
|---|---|---|---|
| Â | P-value | HR (95% CI) | P-value |
Age | 0.007 | Â | 0.027 |
  ≤ 40 vs. > 40,< 65 |  | 3.936(1.291–11.998) | 0.016 |
  > =65 vs. > 40,< 65 |  | 1.900(0.947–3.815) | 0.071 |
Menopausal status | 0.779 | Â | Â |
 Premenopausal vs. Postmenopausal | |||
Breast surgery | 0.433 | Â | Â |
 Lumpectomy vs. Mastectomy |  |  |  |
PT | 0.000 | Â | Â |
 T2 vs. T1 |  | 1.118(0.531–2.354) | 0.769 |
 T3 vs. T1 |  | 16.599(3.864–71.637) | 0.000 |
PN | 0.001 | 3.512(1.707–7.225) | 0.001 |
 N1 vs. N0 | |||
histologic subtype | 0.648 | Â | Â |
 Ductal vs. Lobular/orther | |||
Grade | 0.079 | Â | Â |
 3 vs. 1–2 | |||
Ki67 | 0.033 | 2.079(1.056–4.093) | 0.034 |
  ≥ 20% vs. < 20% | |||
Hormone receptor expression | 0.060 | Â | Â |
 ER(+) PR(−)/ER(−) PR(+) vs. ER(+) PR(+) |  |  |  |
Adjuvant CT | 0.379 | Â | Â |
Yes vs. No | |||
Adjuvant ET | 0.615 | Â | Â |
 Yes vs. No | |||
Adjuvant RT | 0.015 | 1.092(0.481–2.479) | 0.834 |
 Yes vs. No | |||
TOP2A | 0.023 | 2.414(1.228–4.746) | 0.011 |
 High vs. Low | |||