From: The prognostic significance of topoisomerase II alpha protein in early stage luminal breast cancer
 | All patients | TOP2A protein expression | ||
---|---|---|---|---|
 | High | Low | P value | |
n = 434 | n = 127 | n = 307 |  | |
All recurrence n (%) | 47(10.8) | 21(16.5) | 26 (8.5) | 0.018 |
Site of recurrencea n (%) | ||||
 Distant | 38(8.8) | 18 (14.2) | 20 (6.5) | 0.015 |
 Locoregional | 11 (2.5) | 4 (3.1) | 7 (2.3) | 0.737 |
Time of recurrence n (%) | ||||
 0–5 | 31 (7.1) | 12 (9.4) | 17 (6.2) | 0.213 |
 5–8 | 16 (3.7) | 9 (7.1) | 7(2.3) | 0.021 |