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Table 9 Characteristics of included studies- endometrial cancer

From: Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies

Study source Sex Study period Source of subjects No of case No of control/cohort size Cancer site Exposure assessment Exposure Definition Adjustment for covariates Study quality
Case-control studies
 Brons N [174], 2015, Denmark F 2000–2009 Patients from Civil Registration System 5382 72,127 endometrial cancer Prescription Use ≥2 prescriptions on separate dates over the entire study period(ever users) 1,5,25,29,48,49,50,51 8
 Neill AS [175], 2013, Australia F 2005–2007 ANECS 1360 712 endometrial cancer Telephone interview Had ever taken aspirin- not further defined 1,3,10,25,36,48,50,52 7
 Bosetti C [176], 2010, Italy F 1992–2006 Population from Italy 442 676 Endometrial Cancer Questionnaire Use at least once a week for more than 6 months(regular) 1,5,10,25,36,48, 52,53,54,55 5
 Fortuny J [177], 2009, US F 2001–2005 The EDGE Study 469 467 endometrial cancer Interview Use aspirin for 6 months or longer 1,10 7
 Bodelon C [178], 2009, US F 2003–2005 Population from King, Pierce, and Snohomish counties 330 286 Endometrial Cancer In-person interview Use for more than 5 days per month for at least 6 months 1,7,10,25,30 6
 Moysich KB [179], 2005, US F 1982–1998 RPCI Institute 427 427 Endometrial Cancer Questionnaire Use at least once a week for 6 months (regular) 1,5,10,36,37,48 6
Cohort studies
 Brasky TM [92], 2014, US F 1998–2010 WHI 865 85,351 Endometrial cancer Questionnaire Use at both baseline and year 3 visits (consistent) 1,3,4,5, 6, 10,11,18,19,22,24,25,29,30,31, 32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47 9
 Brasky TM [180], 2013, US F 2000–2010 VITAL Cohort 248 22,268 Endometrial Cancer Mailed baseline questionnaire Use≥4 days/week and ≥ 4 years(high use) 1,3,4,5,6,10,11,18,25,29,31,36.37,39,45,47,48, 50,57,58,59 7
 SetiawanVW [169], 2012, Multinational F 1993–2008 MEC 620 64,000 Endometrial cancer Questionnaire Use at least 2 times a week for 1 month or longer 1,3,10,11,25,36,48,52,. 7
 Prizment AE [171], 2010, US F 1992–2006 IWHS 311 21,694 Endometrial cancer Questionnaire Had ever taken aspirin- not further defined 1,6,10,25,36,37,50,52, 56 9
 Danforth KN [181], 2009, US F 1995–2003 AARP 576 72,524 Endometrial cancer Mailed questionnaire Had ever taken aspirin- not further defined 3,4,10,11,18,36,37,45,48,50,52,56 7
 Viswanathan AN [182], 2008, USa F 1980–2004 The NHS 436 82,971 Endometrial cancer Medical record Use at least 1 tablet per week or 1 day per week(current user) 4,10,18,25,37,40,60,61,62 6
 Friis S [62], 2003, Denmarka F 1989–1997 Population of North Jutland County 45 29,470 Endometrial cancer Prescription database 75–150 mg once daily(low-dose aspirin) 1,2 8
 Schreinemachers DM [63], 1994, US F 1971–1987 The National Health and Examination Survey Ι 26 12,668 Endometrial cancer Self reported Use aspirin during the 30-day period before the interview 1,2 6
  1. 1 = age, 2 = sex, 3 = smoking, 4 = family history, 5 = educational level, 6 = alcohol intake, 7 = calendar year, 8 = Fat distribution, 9 = social status, 10 = BMI, 11 = race, 12 = folate, 13 = Charlson comorbidity index, 14 = statin, 15 = metformin, 16 = ACE inhibitors, 17 = Angiotensin II receptor blockers, 18 = physical activity, 19 = fruit, vegetable and/or vitamin intake, 20 = history of colonoscopy, 21 = total energy intake, 22 = ever use of calcium supplements in the past 5 years, 23 = former health checkup, 24 = red meat, 25 = hormone replacement therapy, 26 = unique number of dispensing, 27 = unique number of hospitalizations in the year prior to start of follow up, 28 = mammogram in past 2 y, 29 = other NSAIDs, 30 = area (county/region), 31 = migraine, 32 = Nitro-vasodilator use, 33 = observational study enrollment, 34 = diet modification trial enrollment, 35 = screening for cancer, 36 = age at menarche, 37 = age at menopause, 38 = gravidity, 39 = history of arthritis, 40 = age at first birth, 41 = duration of estrogen therapy, 42 = duration of combined postmenopausal hormone therapy, 43 = hysterectomy status, 44 = use of antihypertensive medication, 45 = history of coronary heart disease, 46 = use of cholesterol-lowering medication, 47 = history of ulcer, 48 = parity, 49 = obesity, 50 = diabetes, 51 = chronic obstructive pulmonary disease, 52 = oral contraceptive use, 53 = study center, 54 = period of interview, 55 = menopausal status, 56 = hypertension, 57 = years of oral contraceptive use, 58 = oophoerectomy, 59 = history of stroke, 60 = waist-hip ratio, 61 = intrauterine device use, 62 = height
  2. AARP AARP diet and health study, ANECS Australian National Endometrial Cancer Study, EDGE Study estrogen, diet, genetics, and endometrial cancer, IWHS Iowa Women’s Health Study, MEC multiethnic cohort study, NHS nurses’ health study, RPCI the Roswell Park Cancer Institute, VITAL the vitamins and lifestyle, WHI women’s health initiative
  3. aStudy deemed to be prone to immortal time bias