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Table 8 Characteristics of included studies- ovarian cancer

From: Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies

Study source Sex Study period Source of subjects No of case No of control/cohort size Cancer site Exposure assessment Exposure Definition Adjustment for covariates Study quality
Case-control studies
 Peres LC [156], 2016, US F 2010–2015 AACES 541 731 Epithelial ovarian cancer Questionnaire Use at least once a week or at least 5 days out of the month, at any point in their lifetime(regular) 1,4,5,10,18, 29,48,49,50,51,52,53,54,55 7
 Baandrup L [157], 2015, Denmark F 2000–2011 The Danish Cancer Registry 4103 58,706 Epithelial ovarian cancer The Danish Prescription Registry Use < 2 prescriptions (non-users) 1,5,7,25,29,43,50,52,55, 56,57,58, 8
 Lo-Ciganic WH [158], 2012, US F 2003–2008 HOPE study 625 1210 Ovarian cancer Questionnaire Use at least 2 tablets per week for 6 months or more(regular) 1, 5,7,10,11,30,39,42,49,50,55,59,60 7
 Ammundsen HB [159], 2012, Denmark F 1995–1999 Danish MALOVA study 756 1564 Ovarian cancer Questionnaire Use two times or more per week for more than 1 month 1,38,50,55,61 6
 Pinheiro SP [160], 2010, US F 1992–2003 New England Case-Control Study 1120 1160 Ovarian cancer Questionnaire Use at least twice aweek(regular) 1, 54 7
 Wu AH [161], 2009, US F 1998–2002 Population from Los Angeles County 582 668 Ovarian cancer Questionnaire Use aspirin medication 2 or more times a week for 1 month or longer 1,4,5,11,49, 50,51,55, 62 8
 Wernli KJ [162], 2008, US F 1998–2001 Population from Wisconsin and Massachusetts 400 2107 Ovarian cancer Telephone interview Use aspirin for more than 6 months and more than twice per week(ever use) 1,4,30, 43,49,51 7
 Merritt MA [163], 2008, Australia F 2002–2005 Australian Ovarian Cancer Study 1564 1502 Ovarian cancer Self-administered questionnaires Ever use of aspirin-not further defined 1,5,50,55 6
 Schildkraut JM [164], 2006, US F 1999–2003 North carolina ovarian cancer study 586 627 Ovarian cancer In-person questionnaires Use at least 3 month of use during the 5-year period(regular) 1,4,5,11,43,49, 50,53,60,63,64 7
 Moysich KB [165], 2001, US F 1982–1998 RPCI buffalo 547 1094 Ovarian cancer Self-administered questionnaires Use at least once a week for 6 consecutive months(regular) 1,4, 40,49,55, 65 6
 Rosenberg L [166], 2000, US F 1976–1998 Patients from hospital in Baltimore, Boston, New York, and Philadelphia 780 4623 Ovarian cancer Questionnaire Use at least 1 day per week for at least 6 months(regular) 1,30,59 7
 Tavani A [167], 2000, US F 1992–1999 Population from Italy 749 898 Ovarian cancer Questionnaires Use at least once a week for more than six consecutive months(regular) 1,5,10,37,50,54, 55,59 6
 Cramer DW [168], 1998, US F 1992–1997 Patients from hospital in eastern Massachusetts and all of New Hampshire 563 523 Ovarian cancer In-person interviews Use at least once a week for at least 6 months 1,5,9,46,54,55,66,67,68 8
Cohort studies
 Brasky TM [92], 2014, US F 1998–2010 WHI 445 116,248 Ovarian cancer Questionnaire Use at both baseline and year 3 visits (consistent) 1,3,4,5, 6, 10,11,18,19,22,24,25,29,30,31,,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47 9
 SetiawanVW [169], 2012, Multinational F 1993–2008 MEC 275 64,000 Ovarian cancer Questionnaire Use at least 2 times a week for 1 month or longer 1,11,25,36,50, 55 7
 Murphy MA [170], 2012, US F 1995–2006 AARP 438 96,710 Ovarian cancer Mailed questionnaires Use one or more pills per week(regular) 1,4,11,25,36,37,43,50,55, 7
 Prizment AE [171], 2010, US F 1992–2006 IWHS 157 21,694 Ovarian cancer Questionnaire Had ever taken aspirin- not further defined 1,10,25,45,55,69 9
 Pinheiro SP [160], 2010, US F 1992–2003 NHS and NHS-II cohorts 217 628 Ovarian cancer Questionnaire Use at least twice a week(regular) 1,25,51 7
 Lacey JV [172], 2004, US F 1979–1998 BCDDP 116 31,364 Ovarian cancer Telephone interview and mailed questionnaires Use at least once a week for 1 year(regular) 1,4,10,11,42,50,51,55 7
 Friis S [62], 2003, Denmarka F 1989–1997 Population from North Jutland County 34 29,470 Ovarian cancer Prescription database 75–150 mg once daily(low-dose aspirin) 1,2 8
 Akhmedkhanov A [173], 2001, US F 1994–1996 The NYU Women’s Health Study 68 680 Epithelial ovarian cancer Self-administered questionnaires Use three or more times per week for at least 6 months 4,36,50, 55 8
  1. 1 = age, 2 = sex, 3 = smoking, 4 = family history, 5 = educational level, 6 = alcohol intake, 7 = chronic obstructive pulmonary disease or asthma, 8 = Fat distribution, 9 = religion, 10 = BMI, 11 = race, 12 = folate, 13 = Charlson comorbidity index, 14 = statin, 15 = metformin, 16 = ACE inhibitors, 17 = Angiotensin II receptor blockers, 18 = physical activity, 19 = fruit, vegetable and/or vitamin intake, 20 = history of colonoscopy, 21 = total energy intake, 22 = ever use of calcium supplements in the past 5 years, 23 = former health checkup, 24 = red meat, 25 = hormone replacement therapy, 26 = unique number of dispensing, 27 = unique number of hospitalizations in the year prior to start of follow up, 28 = mammogram in past 2 y, 29 = other NSAIDs, 30 = area (county/region), 31 = migraine, 32 = Nitro-vasodilator use, 33 = observational study enrollment, 34 = diet modification trial enrollment, 35 = screening for cancer, 36 = age at menarche, 37 = age at menopause, 38 = gravidity, 39 = history of arthritis, 40 = age at first birth, 41 = duration of estrogen therapy, 42 = duration of combined postmenopausal hormone therapy, 43 = hysterectomy status, 44 = use of antihypertensive medication, 45 = history of coronary heart disease, 46 = use of cholesterol-lowering medication, 47 = history of ulcer, 48 = income, 49 = tubal ligation, 50 = oral contraceptive use, 51 = menopausal status, 52 = endometriosis, 53 = pelvic inflammatory disease, 54 = study site, 55 = parity, 56 = infertility, 57 = diabetes mellitus, 58 = tubal sterilization, 59 = interview year, 60 = breastfeeding, 61 = duration of oral contraceptive use, 62 = talc use, 63 = months of pregnancy, 64 = severe menstrual cramping, 65 = presence of irregular menses, 66 = menstrual, headache, or arthritic pain, 67 = ibuprofen, 68 = paracetamol, 69 = partial oophorectomy
  2. AACES the African American Cancer Epidemiology Study, AARP AARP Diet and Health Study, BCDDP the Breast Cancer Detection Demonstration Project, HOPE hormones and Ovarian cancer prediction study, IWHS Iowa Women’s Health Study, MALOVA Danish MALignant Ovarian cancer study, MEC multiethnic cohort study, NHS nurses’ health study, NYU New York University, RPCI the Roswell Park Cancer Institute, WHI women’s health initiative
  3. aStudy deemed to be prone to immortal time bias