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Table 8 Characteristics of included studies- ovarian cancer

From: Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies

Study source

Sex

Study period

Source of subjects

No of case

No of control/cohort size

Cancer site

Exposure assessment

Exposure Definition

Adjustment for covariates

Study quality

Case-control studies

 Peres LC [156], 2016, US

F

2010–2015

AACES

541

731

Epithelial ovarian cancer

Questionnaire

Use at least once a week or at least 5 days out of the month, at any point in their lifetime(regular)

1,4,5,10,18, 29,48,49,50,51,52,53,54,55

7

 Baandrup L [157], 2015, Denmark

F

2000–2011

The Danish Cancer Registry

4103

58,706

Epithelial ovarian cancer

The Danish Prescription Registry

Use < 2 prescriptions (non-users)

1,5,7,25,29,43,50,52,55, 56,57,58,

8

 Lo-Ciganic WH [158], 2012, US

F

2003–2008

HOPE study

625

1210

Ovarian cancer

Questionnaire

Use at least 2 tablets per week for 6 months or more(regular)

1, 5,7,10,11,30,39,42,49,50,55,59,60

7

 Ammundsen HB [159], 2012, Denmark

F

1995–1999

Danish MALOVA study

756

1564

Ovarian cancer

Questionnaire

Use two times or more per week for more than 1 month

1,38,50,55,61

6

 Pinheiro SP [160], 2010, US

F

1992–2003

New England Case-Control Study

1120

1160

Ovarian cancer

Questionnaire

Use at least twice aweek(regular)

1, 54

7

 Wu AH [161], 2009, US

F

1998–2002

Population from Los Angeles County

582

668

Ovarian cancer

Questionnaire

Use aspirin medication 2 or more times a week for 1 month or longer

1,4,5,11,49, 50,51,55, 62

8

 Wernli KJ [162], 2008, US

F

1998–2001

Population from Wisconsin and Massachusetts

400

2107

Ovarian cancer

Telephone interview

Use aspirin for more than 6 months and more than twice per week(ever use)

1,4,30, 43,49,51

7

 Merritt MA [163], 2008, Australia

F

2002–2005

Australian Ovarian Cancer Study

1564

1502

Ovarian cancer

Self-administered questionnaires

Ever use of aspirin-not further defined

1,5,50,55

6

 Schildkraut JM [164], 2006, US

F

1999–2003

North carolina ovarian cancer study

586

627

Ovarian cancer

In-person questionnaires

Use at least 3 month of use during the 5-year period(regular)

1,4,5,11,43,49, 50,53,60,63,64

7

 Moysich KB [165], 2001, US

F

1982–1998

RPCI buffalo

547

1094

Ovarian cancer

Self-administered questionnaires

Use at least once a week for 6 consecutive months(regular)

1,4, 40,49,55, 65

6

 Rosenberg L [166], 2000, US

F

1976–1998

Patients from hospital in Baltimore, Boston, New York, and Philadelphia

780

4623

Ovarian cancer

Questionnaire

Use at least 1 day per week for at least 6 months(regular)

1,30,59

7

 Tavani A [167], 2000, US

F

1992–1999

Population from Italy

749

898

Ovarian cancer

Questionnaires

Use at least once a week for more than six consecutive months(regular)

1,5,10,37,50,54, 55,59

6

 Cramer DW [168], 1998, US

F

1992–1997

Patients from hospital in eastern Massachusetts and all of New Hampshire

563

523

Ovarian cancer

In-person interviews

Use at least once a week for at least 6 months

1,5,9,46,54,55,66,67,68

8

Cohort studies

 Brasky TM [92], 2014, US

F

1998–2010

WHI

445

116,248

Ovarian cancer

Questionnaire

Use at both baseline and year 3 visits (consistent)

1,3,4,5, 6, 10,11,18,19,22,24,25,29,30,31,,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47

9

 SetiawanVW [169], 2012, Multinational

F

1993–2008

MEC

275

64,000

Ovarian cancer

Questionnaire

Use at least 2 times a week for 1 month or longer

1,11,25,36,50, 55

7

 Murphy MA [170], 2012, US

F

1995–2006

AARP

438

96,710

Ovarian cancer

Mailed questionnaires

Use one or more pills per week(regular)

1,4,11,25,36,37,43,50,55,

7

 Prizment AE [171], 2010, US

F

1992–2006

IWHS

157

21,694

Ovarian cancer

Questionnaire

Had ever taken aspirin- not further defined

1,10,25,45,55,69

9

 Pinheiro SP [160], 2010, US

F

1992–2003

NHS and NHS-II cohorts

217

628

Ovarian cancer

Questionnaire

Use at least twice a week(regular)

1,25,51

7

 Lacey JV [172], 2004, US

F

1979–1998

BCDDP

116

31,364

Ovarian cancer

Telephone interview and mailed questionnaires

Use at least once a week for 1 year(regular)

1,4,10,11,42,50,51,55

7

 Friis S [62], 2003, Denmarka

F

1989–1997

Population from North Jutland County

34

29,470

Ovarian cancer

Prescription database

75–150 mg once daily(low-dose aspirin)

1,2

8

 Akhmedkhanov A [173], 2001, US

F

1994–1996

The NYU Women’s Health Study

68

680

Epithelial ovarian cancer

Self-administered questionnaires

Use three or more times per week for at least 6 months

4,36,50, 55

8

  1. 1 = age, 2 = sex, 3 = smoking, 4 = family history, 5 = educational level, 6 = alcohol intake, 7 = chronic obstructive pulmonary disease or asthma, 8 = Fat distribution, 9 = religion, 10 = BMI, 11 = race, 12 = folate, 13 = Charlson comorbidity index, 14 = statin, 15 = metformin, 16 = ACE inhibitors, 17 = Angiotensin II receptor blockers, 18 = physical activity, 19 = fruit, vegetable and/or vitamin intake, 20 = history of colonoscopy, 21 = total energy intake, 22 = ever use of calcium supplements in the past 5 years, 23 = former health checkup, 24 = red meat, 25 = hormone replacement therapy, 26 = unique number of dispensing, 27 = unique number of hospitalizations in the year prior to start of follow up, 28 = mammogram in past 2 y, 29 = other NSAIDs, 30 = area (county/region), 31 = migraine, 32 = Nitro-vasodilator use, 33 = observational study enrollment, 34 = diet modification trial enrollment, 35 = screening for cancer, 36 = age at menarche, 37 = age at menopause, 38 = gravidity, 39 = history of arthritis, 40 = age at first birth, 41 = duration of estrogen therapy, 42 = duration of combined postmenopausal hormone therapy, 43 = hysterectomy status, 44 = use of antihypertensive medication, 45 = history of coronary heart disease, 46 = use of cholesterol-lowering medication, 47 = history of ulcer, 48 = income, 49 = tubal ligation, 50 = oral contraceptive use, 51 = menopausal status, 52 = endometriosis, 53 = pelvic inflammatory disease, 54 = study site, 55 = parity, 56 = infertility, 57 = diabetes mellitus, 58 = tubal sterilization, 59 = interview year, 60 = breastfeeding, 61 = duration of oral contraceptive use, 62 = talc use, 63 = months of pregnancy, 64 = severe menstrual cramping, 65 = presence of irregular menses, 66 = menstrual, headache, or arthritic pain, 67 = ibuprofen, 68 = paracetamol, 69 = partial oophorectomy
  2. AACES the African American Cancer Epidemiology Study, AARP AARP Diet and Health Study, BCDDP the Breast Cancer Detection Demonstration Project, HOPE hormones and Ovarian cancer prediction study, IWHS Iowa Women’s Health Study, MALOVA Danish MALignant Ovarian cancer study, MEC multiethnic cohort study, NHS nurses’ health study, NYU New York University, RPCI the Roswell Park Cancer Institute, WHI women’s health initiative
  3. aStudy deemed to be prone to immortal time bias