From: Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies
Study source | Sex | Study period | Source of subjects | No of case | No of control/cohort size | Cancer site | Exposure assessment | Exposure Definition | Adjustment for covariates | Study quality |
---|---|---|---|---|---|---|---|---|---|---|
Case-control studies | ||||||||||
 Peres LC [156], 2016, US | F | 2010–2015 | AACES | 541 | 731 | Epithelial ovarian cancer | Questionnaire | Use at least once a week or at least 5 days out of the month, at any point in their lifetime(regular) | 1,4,5,10,18, 29,48,49,50,51,52,53,54,55 | 7 |
 Baandrup L [157], 2015, Denmark | F | 2000–2011 | The Danish Cancer Registry | 4103 | 58,706 | Epithelial ovarian cancer | The Danish Prescription Registry | Use < 2 prescriptions (non-users) | 1,5,7,25,29,43,50,52,55, 56,57,58, | 8 |
 Lo-Ciganic WH [158], 2012, US | F | 2003–2008 | HOPE study | 625 | 1210 | Ovarian cancer | Questionnaire | Use at least 2 tablets per week for 6 months or more(regular) | 1, 5,7,10,11,30,39,42,49,50,55,59,60 | 7 |
 Ammundsen HB [159], 2012, Denmark | F | 1995–1999 | Danish MALOVA study | 756 | 1564 | Ovarian cancer | Questionnaire | Use two times or more per week for more than 1 month | 1,38,50,55,61 | 6 |
 Pinheiro SP [160], 2010, US | F | 1992–2003 | New England Case-Control Study | 1120 | 1160 | Ovarian cancer | Questionnaire | Use at least twice aweek(regular) | 1, 54 | 7 |
 Wu AH [161], 2009, US | F | 1998–2002 | Population from Los Angeles County | 582 | 668 | Ovarian cancer | Questionnaire | Use aspirin medication 2 or more times a week for 1 month or longer | 1,4,5,11,49, 50,51,55, 62 | 8 |
 Wernli KJ [162], 2008, US | F | 1998–2001 | Population from Wisconsin and Massachusetts | 400 | 2107 | Ovarian cancer | Telephone interview | Use aspirin for more than 6 months and more than twice per week(ever use) | 1,4,30, 43,49,51 | 7 |
 Merritt MA [163], 2008, Australia | F | 2002–2005 | Australian Ovarian Cancer Study | 1564 | 1502 | Ovarian cancer | Self-administered questionnaires | Ever use of aspirin-not further defined | 1,5,50,55 | 6 |
 Schildkraut JM [164], 2006, US | F | 1999–2003 | North carolina ovarian cancer study | 586 | 627 | Ovarian cancer | In-person questionnaires | Use at least 3 month of use during the 5-year period(regular) | 1,4,5,11,43,49, 50,53,60,63,64 | 7 |
 Moysich KB [165], 2001, US | F | 1982–1998 | RPCI buffalo | 547 | 1094 | Ovarian cancer | Self-administered questionnaires | Use at least once a week for 6 consecutive months(regular) | 1,4, 40,49,55, 65 | 6 |
 Rosenberg L [166], 2000, US | F | 1976–1998 | Patients from hospital in Baltimore, Boston, New York, and Philadelphia | 780 | 4623 | Ovarian cancer | Questionnaire | Use at least 1 day per week for at least 6 months(regular) | 1,30,59 | 7 |
 Tavani A [167], 2000, US | F | 1992–1999 | Population from Italy | 749 | 898 | Ovarian cancer | Questionnaires | Use at least once a week for more than six consecutive months(regular) | 1,5,10,37,50,54, 55,59 | 6 |
 Cramer DW [168], 1998, US | F | 1992–1997 | Patients from hospital in eastern Massachusetts and all of New Hampshire | 563 | 523 | Ovarian cancer | In-person interviews | Use at least once a week for at least 6 months | 1,5,9,46,54,55,66,67,68 | 8 |
Cohort studies | ||||||||||
 Brasky TM [92], 2014, US | F | 1998–2010 | WHI | 445 | 116,248 | Ovarian cancer | Questionnaire | Use at both baseline and year 3 visits (consistent) | 1,3,4,5, 6, 10,11,18,19,22,24,25,29,30,31,,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47 | 9 |
 SetiawanVW [169], 2012, Multinational | F | 1993–2008 | MEC | 275 | 64,000 | Ovarian cancer | Questionnaire | Use at least 2 times a week for 1 month or longer | 1,11,25,36,50, 55 | 7 |
 Murphy MA [170], 2012, US | F | 1995–2006 | AARP | 438 | 96,710 | Ovarian cancer | Mailed questionnaires | Use one or more pills per week(regular) | 1,4,11,25,36,37,43,50,55, | 7 |
 Prizment AE [171], 2010, US | F | 1992–2006 | IWHS | 157 | 21,694 | Ovarian cancer | Questionnaire | Had ever taken aspirin- not further defined | 1,10,25,45,55,69 | 9 |
 Pinheiro SP [160], 2010, US | F | 1992–2003 | NHS and NHS-II cohorts | 217 | 628 | Ovarian cancer | Questionnaire | Use at least twice a week(regular) | 1,25,51 | 7 |
 Lacey JV [172], 2004, US | F | 1979–1998 | BCDDP | 116 | 31,364 | Ovarian cancer | Telephone interview and mailed questionnaires | Use at least once a week for 1 year(regular) | 1,4,10,11,42,50,51,55 | 7 |
 Friis S [62], 2003, Denmarka | F | 1989–1997 | Population from North Jutland County | 34 | 29,470 | Ovarian cancer | Prescription database | 75–150 mg once daily(low-dose aspirin) | 1,2 | 8 |
 Akhmedkhanov A [173], 2001, US | F | 1994–1996 | The NYU Women’s Health Study | 68 | 680 | Epithelial ovarian cancer | Self-administered questionnaires | Use three or more times per week for at least 6 months | 4,36,50, 55 | 8 |