Table 7 Characteristics of included studies- breast cancer
From: Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies
Study source | Sex | Study period | Source of subjects | No of case | No of control/cohort size | Cancer site | Exposure assessment | Exposure Definition | Adjustment for covariates | Study quality |
|---|---|---|---|---|---|---|---|---|---|---|
Case-control studies | ||||||||||
Iqbal U [47], 2017, China | F | 2001–2011 | The Taiwan NHI database | 65,491 | 435,364 | Breast cancer | Prescription | Patients had aspirin prescribed at least for 2 months during the 3-year period before the initial cancer diagnosis | 1,2,13,14, 15,16,17 | 7 |
Dierssen-Sotos T [132], 2016, Spain | F | 2008–2013 | The MCC study | 1736 | 1909 | Breast cancer | Questionnaire | Use of aspirin- not further defined | 1,3,4,5,10,30,36,40,50,51 | 8 |
Cui Y [133], 2014, US | F | 2001–2011 | Nashville Breast Health Study | 2154 | 1831 | Breast cancer | Telephone interview | Use aspirin three or more times a week for a minimum duration of 1 year(regular) | 1,3,4,5,6,11,18,25,40,50,51,52,53 | 7 |
Brasky TM [134], 2010, US | F | 1996–2001 | WEB Study | 1057 | 2094 | Breast cancer | Self-reported | Use 0 days/month (non-users) | 1,4,5,11,25,29,36,37,38,53, | 6 |
Cronin-Fenton DP [135], 2010, Denmark | F | 1991–2006 | Population from North Jutland and Aarhus counties, Denmark | 8195 | 81,950 | Breast cancer | Danish healthcare databases | Use at least 2 prescriptions within 2 years of diagnosis(recent use) | 25,31,39 | 8 |
Slattery ML [136], 2007, US | F | 1999–2004 | Population from the southwestern United States (4-Corner’s Breast Cancer Study) | 2325 | 2525 | Breast cancer | Questionnaire | Use at least thrice weekly for at least 1 month(regular) | 1,10,18,38,54,55,56 | 7 |
Harris RE [137], 2006, US | F | 2003–2004 | CHRI | 277 | 493 | Breast cancer | Questionnaire | Use at least two times per week for 2 years or more | 1,3,5,6,10,38,51 | 7 |
Swede H [138], 2005, US | F | 1982–1998 | The Roswell Park Cancer Institute | 1478 | 3383 | Breast cancer | Questionnaire | Use aspirin at least once a week for at least 1 year(regular) | 5,10,36,40,53 | 6 |
Zhang YQ [139], 2005, US | F | 1976–2002 | The Case-Control Surveillance Study Revisited | 2406 | 1554 | Breast cancer | Questionnaire | Use at least four times per week for 3 or more continuous months(regular) | 1,4,5,6,10,11, 36,37,38,40,41,53,54,61,62,63,64 | 5 |
Terry MB [140], 2004, US | F | 1996–1997 | The Long Island Breast Cancer Study Project | 1442 | 1420 | Breast cancer | Questionnaire | Use at least once a week for 6 months or longer(ever use) | 1,10,29,31 | 6 |
Moorman PG [141], 2003, US | F | 1996–2000 | Phase II of the Carolina Breast Cancer and Carcinoma In Situ Study | 500 | 2631 | Breast cancer | Questionnaire | Use at least 8 days a month for three or more months(regular) | 1 | 6 |
Cotterchio M [142], 2001, Canada | F | 1996–1998 | Population in Canada | 2696 | 2600 | Breast cancer | Questionnaire | Daily use for≥ 2 months(any use) | 1,39,53 | 6 |
Neugut AI [80], 1998, US | F | 1989–1992 | Columbia-Prebyterian Medical Center | 252 | 176 | Breast cancer | Medical record | Use aspirin-not further defined | 1,4,5 | 6 |
Cohort studies | ||||||||||
Cao Y [8], 2016, US | F | 1980–2010 1986–2012 | NHS and HPFS | 7424 | 135,965 | Breast cancer | Questionnaire | Use at least 2 times per week(regular) | 3,5,6,7,8,9,10,11,12,18,19,20,21,22,23,24,25,28 | 9 |
Kim S [143], 2015, US | F | 2003–2013 | Sister Study | 2118 | 50,884 | Breast cancer | Questionnaire | Use at least once a week(current user) | 4,5,10,11,40,51,53, 67 | 8 |
Hollestein LM [91], 2014, Netherlandsa | F | 1998–2010 | PHARMO and the Eindhoven Cancer Registry | 585 | 55,597 | Breast cancer | Prescription database | Low dose aspirin (≤ 100 mg daily)- not further defined | 1,2,26,27 | 8 |
Brasky TM [92], 2014, US | F | 1998–2010 | WHI | 5401 | 142,330 | Breast cancer | Self-administered questionnaires | Use at both baseline and year 3 visits (consistent) | 1,3,4,5, 6,7,10,11,18,19,22,24,25,29,30,31,,32,33,34,35,36,37,38,39,40,4142,43,44,45,46,47 | 9 |
Bardia A [144], 2011, US | F | 1986–2005 | The IWHS | 1581 | 26,580 | Breast cancer | Questionnaire | Ever use aspirin- not further defined | 1,3,4,5,6,10, 18,25,36,37,38,39,40,68,69 | 8 |
Bosco JL [145], 2011, US | F | 1995–2007 | BWHS | 1275 | 59,000 | Breast cancer | Questionnaire | Use aspirin ≥ 3 days per week (regular) | 1,3,4,10,18,25,29,70 | 9 |
Eliassen AH [146], 2009, US | F | 1989–2003 | NHS II | 1229 | 112,292 | Breast cancer | Questionnaire | Use aspirin ≥2 times per week(regular) | 5,6,7,10,36,38,40,53, 68,71 | 9 |
Friisa S [147], 2008, Denmark | F | 1993–2003 | The prospective Diet, Cancer and Health cohort study | 396 | 28,695 | Breast cancer | Questionnaire | Use more than one pill per month | 1,4,25,38,50,53 | 7 |
Gierach GL [148], 2008, US | F | 1995–2003 | AARP | 4451 | 126,124 | Breast cancer | Questionnaire | Ever use aspirin- not further defined | 1,5,6,11,25,29,40,49, 72 | 7 |
Ready A [149], 2008, US | F | 2000–2004 | VITAL cohort | 479 | 35,323 | Breast cancer | Questionnaire | Use at least once a week for a year during the last 10 years(any use) | 1,5,6,10,11,19,28,29,36,37,40,72, 73,74 | 7 |
Siemes C [96], 2008, Netherland | F | 1992–2004 | The Rotterdam Study | 175 | 7621 | Breast cancer | Questionnaire and prescriptions. | The absence of a prescription for any non-aspirin or aspirin NSAID(no use) | 1,3,10,25,36,37,50, 75 | 8 |
Jacobs EJ [98], 2007, US | F | 1992–2003 | Cancer Prevention Study II Nutrition Cohort | 3121 | 76,303 | Breast cancer | Questionnaire | Use at least 30 “times” per month(daily use of adult-strength) | 1,3,4,10,11,18,20,25, 28,29,45,48,49 | 8 |
Gill JK [150], 2007, US | F | 1993–2002 | Multiethnic Cohort | 1457 | 98,920 | Breast cancer | Questionnaire | Use at least two times per week for 1 month or longer | 1,4,5,6,10,11, 25,28,36,37,40,50,51,76 | 7 |
Gallicchio L [151], 2007, US | F | 1989–2006 | CLUE II (“Give us a Clue to Cancer and Heart Disease”) | 418 | 15,651 | Breast cancer | Questionnaire | Use aspirin in the last 48 h(current user) | 1 | 7 |
Marshall SF [152], 2005, US | F | 1995–2001 | The California Teachers Study | 2391 | 114,640 | Breast cancer | Questionnaire | Use at least once a Week(regular) | 1,3,5,6,10,11,18, 25,28,51,53,59,77 | 9 |
Rahme E [153], 2005, Canadaa | F | 1998–2202 | RAMQ | 664 | 23,573 | Breast cancer | Prescription database | Ever use aspirin during the year prior to the index date | 1,25,28,53,57,58,60 | 7 |
Rodríguez LA [154], 2004, UKa | F | 1995–2001 | GPRD | 3708 | 23,708 | Breast cancer | Prescription database | No recorded use at any time before the index date(nonuser) | 1,3,6,10,25,29,53, 62,65,66 | 8 |
Harris RE [155], 1999, US | F | 1991–1996 | Population from The Ohio State University Comprehensive Cancer Center in Columbus, Ohio | 316 | 32,505 | Breast cancer | Questionnaire | Use aspirin ≥1 pill per week | 1 | 5 |
Schreinemachers DM [63], 1994, US | F | 1971–1987 | The National Health and Examination Survey Ι | 147 | 12,668 | Breast cancer | Self reported | Use aspirin during the 30-day period before the interview | 1,2 | 6 |
Paganini-Hill A [103], 1989, US | F | 1981–1988 | Population from Leisure World, Laguna Hills, US | 214 | 13,870 | Breast cancer | Questionnaire | Aspirin use: none,<daily, daily | 2 | 4 |