From: Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies
Study source | Sex | Study period | Source of subjects | No of case | No of control/cohort size | Cancer site | Exposure assessment | Exposure Definition | Adjustment for covariates | Study quality |
---|---|---|---|---|---|---|---|---|---|---|
Case-control studies | ||||||||||
Iqbal U [47], 2017, China | M/F | 2001–2011 | The Taiwan NHI database | 68,409 | 273,636 | Lung cancer | Prescription | Patients had aspirin prescribed at least for 2 months during the 3-year period before the initial cancer diagnosis | 1,2,13,14,15,16,17 | 7 |
Lim WY [119], 2012, Singapore | F | 2005–2008 | Population from Chinese | 252 | 556 | Lung cancer | Questionnaire | Use twice a week or more, for a month or more(regular) | 1, 3,4,5,19,34 | 7 |
McCormack VA [120], 2011, US | M/F | – | AHFTS | 977 | 683 | Lung cancer | Interview | – | 1,3,5,11 | 7 |
McCormack VA [120], 2011, US | M/F | – | Population from Boston | 768 | 123 | Lung cancer | – | – | 1,3,5,11 | 7 |
McCormack VA [120], 2011, US | M/F | – | Population from Florida | 467 | 889 | Lung cancer | – | – | 1,3,5,11 | 7 |
McCormack VA [120], 2011, US | M/F | – | Population from Hawaii | 629 | 588 | Lung cancer | – | – | 1,3,5,11 | 7 |
McCormack VA [120], 2011, US | M/F | – | MSKCC | 102 | 101 | Lung cancer | – | – | 1,3,5,11 | 7 |
McCormack VA [120], 2011, US | M/F | – | NELCS | 276 | 251 | Lung cancer | – | – | 1,3,5,11 | 7 |
McCormack VA [120], 201, Israel | M/F | – | NICCC | 280 | 270 | Lung cancer | – | – | 1,3,5,11 | 7 |
Kelly JP [121], 2008, US | M/F | 1976–2007 | Patients in Boston Baltimore New York and Philadelphia | 1884 | 6251 | Lung cancer | In-person interview | Use at least 4 days per week for at least three continuous months(regular) | 1,2,3,4,6,29, 30,36 | 6 |
Van Dyke AL [122], 2008, US | F | 2001–2005 | Metropolitan Detroit Cancer Surveillance System, a participant in the National Cancer Institute’s Surveillance | 580 | 541 | Lung Cancer | Questionnaire | Had taken any aspirin | 1,3,4,5,10,11, 3135,37 | 7 |
Harris RE [123], 2007, US | M/F | 2002–2004 | The Ohio State University Medical Center, Columbus, Ohio | 375 | 654 | Lung Cancer | Interview | Use no more than one pill per week for less than 1 year(nonuser) | 1,2,3,5,6,10,11,35 | 7 |
Muscat JE [124], 2003, US | M/F | 1992–2000 | Hospitals in New York and Washington, D.C | 997 | 918 | Lung Cancer | Questionnaire | Use three tablets per week for 1 or more years(regular) | 1,2,3,4 | 7 |
Moysich KB [125], 2002, US | M/F | 1982–1998 | RPCI | 868 | 935 | Lung Cancer | Epidemiological questionnaire | Use at least once a week for one year(regular) | 1,3,4 | 8 |
Cohort studies | ||||||||||
Cao Y [8], 2016, US | M/F | 1980–2010 1986–2012 | NHS and HPFS | 2430 | 135,965 | Lung cancer | Questionnaire | Use at least 2 times per week(regular) | 3,5,6,7,8,9,10,11,12,18,19,20,21,22,23,24,25,28 | 9 |
F | 1993–2010 | WHI | 1902 | 143,841 | Lung cancer | Questionnaire | Use at least twice a week in each of the two weeks preceding the interview(regular) | 1,3,5,6,10,11,19,25,31,50,51,52 | 8 | |
Hollestein LM [91], 2014, Netherlandsa | M/F | 1998–2010 | PHARMO and the Eindhoven Cancer Registry | 915 | 109,276 | Lung cancer | Prescription database | Low dose aspirin (≤ 100 mg daily)- not further defined | 1,2,26,27 | 8 |
Brasky TM [127], 2012, US | M/F | 2000–2007 | The VITAL cohort | 100 | 69,919 | Lung cancer | The baseline questionnaire | Use aspirin ≥1 day/week for ≥ 1 year(regular) | 1,2,3,4,5,10,11, 29,35,46,53,54 | 8 |
McCormack VA [120], 2011, US | M/F | – | DDCHS | 812 | 55,396 | Lung cancer | Questionnaire | – | 1,3,5,11, | 7 |
Siemes C [96], 2008, Netherland | M/F | 1992–2004 | The Rotterdam Study | 134 | 7621 | Lung cancer | Questionnaire and prescriptions. | The absence of a prescription for any non-aspirin or aspirin NSAID(no use) | 1,2,10,18,21,25, 35,55,56,57 | 8 |
Olse JH [128], 2008, Dermarka | M/F | 2002–2005 | Danish Diet, Cancer and Health prospective cohort study | 282 | 390 | Lung cancer | Questionnaire and prescription database | Any use of aspirin or 1 year or more before the index date | 1,2,3,4,38,39 | 7 |
Hernández-Díaz S [129], 2007, UKa | M/F | 1995–2004 | THIN database | 4336 | 10,000 | Lung cancer | THIN database | Had recorded prescription at any time before the index date | 1,2,3,6,10, 14,33,35,40,41,42,43,44,45,46,47,48 | 8 |
Jacobs EJ [98], 2007, US | M/F | 1992–2003 | Cancer Prevention Study II Nutrition Cohort | 1815 | 146,113 | Lung cancer | Questionnaire | Use at least 30 “times” per month(daily use of adult-strength) | 1,2,3,4,9,10,11, 18,25,28,29, 31,32,33 | 8 |
Hayes JH [130], 2006, US | F | 1992–2002 | IWHS | 403 | 27,162 | Lung cancer | Questionnaire | Never, less than one weekly, once weekly, two to five times weekly, and six or more times weekly | 1,3,4,6,10,19, 29,58 | 7 |
Akhmedkhanov A [131], 2002, US | F | 1994–1996 | NYU and Women’s Health Study cohort. | 81 | 808 | Lung cancer | Questionnaire | Use three or more times per week for a period of 6 months or longer | 1,3,4,49 | 7 |
Schreinemachers DM [63], 1994, US | M/F | 1971–1987 | The National Health and Examination Survey Ι | 163 | 12,668 | Lung cancer | Self reported | Use aspirin during the 30-day period before the interview | 1,2 | 6 |
Paganini-Hill A [103], 1989, US | M/F | 1981–1988 | Population in Leisure World, Laguna Hills, US | 111 | 13,870 | Lung cancer | Questionnaire | Aspirin use: none,<daily, daily | 2 | 4 |