Table 4 Characteristics of included studies- hepato-biliary cancer
From: Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies
Study source | Sex | Study period | Source of subjects | No of case | No of control/cohort size | Cancer site | Exposure assessment | Exposure Definition | Adjustment for covariates | Study quality |
|---|---|---|---|---|---|---|---|---|---|---|
Case-control studies | ||||||||||
 Choi J [104], 2016, US | M/F | 2000–2014 | Patients seen at the Mayo Clinic | 2395 | 4769 | Cholangiocarcinoma | Electronic medical record | Use at least once per week at the index date | 1,2,3,11,12,13,14,15 | 9 |
 Yang B [105], 2016, UK | M/F | 1988–2011 | CPRD | 814 | 3180 | Primary liver cancer | Medical records database | Had two or more aspirin prescriptions recorded prior to the index date(ever use) | 3,6,10,15,16,17,18 | 7 |
 Burr NE [106], 2014, UK | M/F | 2004–2010 | NNUH and LGH | 81 | 275 | Cholangiocarcinoma | Letters from general practitioners (GPs), hospital clerkings, surgical records, nursing notes and radiological reports | Drug was recorded in any of the data sources | 1,2,3,15 | 7 |
Cohort studies | ||||||||||
 Kim G [107], 2017, Korea | M/F | 2003–2012 | NHIS-NSC | 229 | 1145 | Hepatocellular carcinoma | Prescription | At least one prescription of aspirin between the cohort entry and the index date | 1,2,19,20, | 6 |
 Petrick JL [108], 2015, US | M/F | from 1993 | AARP,AHS, USRT,BCDDP, PLCO,HPFS, CPSII, BWHS WHI,NHS | 904 | 1,084,133 | Hepatocellular carcinoma and intrahepatic cholangiocarcinoma | Questionnaire | Any reported aspirin use in the 12 months prior to baseline | 1,2,3,6,10,11,15, 21 | 7 |
 Liu E [109], 2005, China | M/F | 1997–2001 | Population from Shanghai | 368 | 1013 | Gallbladder Cancer | Questionnaire | Use at least twice a week for longer than a month 1 year before interview | 1,2,5, 22 | 6 |
 S Friis [62], 2003, Denmarka | M/F | 1989–1997 | Population from North Jutland County | 21 | 29,470 | Liver cancer | Prescription database | 75–150 mg once daily(low-dose aspirin) | 1,2 | 8 |