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Table 19 Characteristics of included studies- lymphoma

From: Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies

Study source Sex Study period Source of subjects No of case No of control/cohort size Cancer site Exposure assessment Exposure Definition Adjustment for covariates Study quality
Case-control studies
 Baecklund E [245], 2006, Swedish M/F 196–1995 From the Swedish Inpatient Register 269 225 Lymphoma Hospital records Use aspirin for 4 consecutive weeks 15,16 5
 Zhang YQ [246], 2006, US M/F 197–2002 Subjects were recruited from patients admitted to hospitals in New York, Philadelphia, Boston and Baltimore 412 1524 Non-Hodgkin lymphoma Nurse-interviewers administered standard questionnaires Use at least four times per week for at least three or more continuous months(regular) 1,2,7,8 7
 Flick ED [247], 2006, US+ M/F 200–2004 Population from the California counties of San Francisco, Alameda, Marin, Contra Costa, San Mateo, and Santa Clara 604 638 Non-Hodgkin lymphoma Interview Use at least 2 days per week for 3 months or longer during the past 20 years 1,2,17 7
 Baker JA [248], 2005, US M/F 198–1998 RPCI 628 2512 Non-Hodgkin lymphoma Questionnaire Use at least once per week for 6 months 1 5
 Chang ET [249], 2004, US M/F 1997–2000 population from the greater Boston, Massachusetts, metropolitan area and in the state of Connecticut 565 679 Hodgkin’s lymphoma Telephone interview Use two or more tablets per Week(regular) 1,2,3,9,17 6
 Zhang YW [250], 2004, US M/F 1996–2000 Patients in Yale Cancer Center’s Rapid Case Ascertainment Shared Resource(RCA) 601 717 Non-Hodgkin lymphoma Iinterview Use at least once a day for a period of 6 months or longer previous to 1 year ago 1,4,10,18 7
Cohort studies
 Hollestein LM [91], 2014, Netherlands a M/F 1998–2010 PHARMO and the Eindhoven Cancer Registry 256 109,276 Lymphoma Prescription database Low dose aspirin (≤100 mg daily)- not further defined 1,2,11,12 8
 Birmann BM [251], 2014, US F 1976–2008 NHS 196 85,942 Multiple myeloma Questionnaire 81-mg “baby” and 325-mg “adult” strength 1,10 8
  M 1986–2008 HPFS 132 47,029 Multiple myeloma Questionnaire 81-mg “baby” and 325-mg “adult” strength 1,10 8
 Teras LR [252], 2013, US M/F 1992–2007 The CPS-II Nutrition Cohort Cancer Prevention Study-II (CPS-II) Nutrition Cohort 1709 149,570 Lymphoma Questionnaire Use aspirin ≥30 aspirin pills/Month(regular) 1,3,4,5,6,10,19,20, 21,22,23,24,25 7
 Chang ET [253], 2011, Denmarka M/F 1995–2008 Population from Denmark 1659 8089 Hodgkin lymphoma Prescription database Use aspirin ≥ 2 times per week 1,2,13,14 8
 Walter RB [254], 2011, US M/F 2000–2002 VITAL Study 224 64,839 Lymphoma Questionnaire Had ever taken low dose aspirin(81 mg) 4,21,23,26,27,28,29,33 6
 Erber E [255], 2009, US M/F 199–1996 MEC Study 896 193,050 Non-Hodgkin Lymphoma Self-completed questionnaire Use at least two times per week for 1 month or longer 5,6,10 8
 Cerhan JR [256], 2003, US M/F 199–1999 IWHS 130 27,290 Non-Hodgkin Lymphoma Self-completed questionnaire Had ever taken aspirin- not further defined 1,3,6,17,21,25, 29,30,31,32 7
 Friis S [62], 2003, Denmarka M/F 1989–1997 Population from North Jutland County 57 29,470 Non-Hodgkin’s lymphoma Prescription database 75–150 mg once daily(low-dose aspirin) 1,2 8
 Schreinemachers DM [63], 1994, US M/F 1971–1987 The National Health and Examination Survey Ι 48 12,668 Lymphoma Self reported Use aspirin during the 30-day period before the interview 1,2 6
  1. 1=age, 2=sex, 3=smoking, 4=family history, 5=educational level, 6=alcohol intake, 7=year of interview, 8=study center, 9=use of other analgesics, 10=BMI, 11=unique number of dispensing, 12=unique number of hospitalizations in the year prior to start of follow up, 13=Charlson comorbidity index, 14= history of connective tissue disorder, 15=auranofin, chlorambucil, cyclophosphamide, cyclosporine, D-penicillamine, and podophyllotoxin, 16=disease activity, 17=residence, 18=menopausal status, 19=race, 20=sitting time, 21=diabetes status, 22=rheumatoid arthritis status, 23=cholesterol-lowering drug use, 24=acetaminophen use, 25=postmenopausal hormone use, 26=self-reported health, 27=history of coronary artery disease, 28=stroke, 29=marital status, 30=transfusion history,31= red meat and fruit intake,32= replacement therapy, 33=history of fatigue/lack of energy
  2. HPFS Health Professionals follow-up study, IWHS Iowa Women’s Health Study, MEC multiethnic cohort study, NHS nurses’ health study, RPCI the Roswell Park Cancer Institute, VITAL the vitamins and lifestyle
  3. aStudy deemed to be prone to immortal time bias