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Table 15 Characteristics of included studies- brain tumor

From: Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies

Study source Sex Study period Source of subjects No of case No of control/cohort size Cancer site Exposure assessment Exposure Definition Adjustment for covariates Study quality
Case-control studies
 Egan KM [41], 2016, US M/F 2004–2012 Population in Southeastern US 1433 1296 Brain tumor Interview Use at least twice a week for 12 consecutive months (regular) 1,2,5,7,8 6
 Gaist D [222], 2013, Denmark M/F 2000–2009 Danish Cancer Registry, Civil Registration System, National Prescription Registry, Danish National Registry of Patients, and Danisheducation and fertility registries within Statistics Denmark 2688 18,848 Glioma National Prescription Registry Use aspirin as a ‘low’ (≤ 100 mg) or ‘high’ (150 mg) daily dose of low-dose aspirin 5,10,13,14,15,16,17,18 7
 Ferris J [223], 2012, US M/F 2007–2010 CUMC 236 230 Glioma Questionnaire Use at least twice a weekfor 6 months or longer(ever use) 1,2,7,9,11,12,13 7
    The UCSF 281 170 Glioma Questionnaire Use at leasttwice a week for 6 months or longer(ever use) 1,2,7,9,11,12,13  
Cohort studies
 Bannon FJ [224], 2013, UKa M/F 1987–2009 UK Clinical Practice Research Datalink(CPRD) 5052 42,678 Brain tumor Prescription database Had ever taken aspirin- not further defined 1,2,8 7
 Daugherty SE [225], 2011, US M/F 1996–2006 AARP 605 302,767 Glioma Questionnaire Use aspirin ≥ 2 times/wk.(regular) 1,2,7,19 7
 Friis S [62], 2003, Denmarka M/F 1989–1997 Population from North Jutland County 70 29,470 Brain tumor Prescription database 75–150 mg once daily(low-dose aspirin) 1,2 8
  1. 1 = age, 2 = sex, 3 = smoking, 4 = family history, 5 = educational level, 6 = alcohol intake, 7 = race, 8 = state of residence, 9 = center, 10 = anti-asthma medications, 11 = individual NSAIDs, 12 = acetaminophen, 13 = statins, 14 = diabetes, 15 = stroke, 16 = allergy, 17 = asthma, 18 = antihistamines, 19 = history of heart disease using age as time metric
  2. AARP AARP diet and health study, CPRD clinical practice research datalink, CUMC Columbia University Medical Center, UCSF University of California San Francisco
  3. aStudy deemed to be prone to immortal time bias