Table 11 Characteristics of included studies- prostate cancer
From: Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies
Study source | Sex | Study period | Source of subjects | No of case | No of control/cohort size | Cancer site | Exposure assessment | Exposure Definition | Adjustment for covariates | Study quality |
|---|---|---|---|---|---|---|---|---|---|---|
Case-control studies | ||||||||||
Iqbal U [47], 2017, China | M | 2001–2011 | The Taiwan NHI database | 32,419 | 129,676 | Prostate cancer | Prescription | Patients had aspirin prescribed at least for 2 months during the 3-year period before the initial cancer diagnosis | 1,2,13,14, 15,16,17 | 7 |
Skriver C [185], 2016, Denmark | M | 2000–2012 | Danish nationwide registries | 35,600 | 177,992 | Prostate cancer | Prescription | Use aspirin ≥ 2 prescriptions redeemed on separate dates(ever use) | 1, 4,14,28,30,36,37,38,,40, | 8 |
Veitonmäki T [186], 2013, Finland | M | 1995–2002 | Finnish Cancer Registry | 13,478 | 24,657 | Prostate cancer | Prescription database | Ever use aspirin- not further defined | 1,32 | 8 |
Murad AS [187], 2011, UK | M | 2001–2008 | ProtecT | 1016 | 5043 | Prostate cancer | Questionnaire | Ever use aspirin- not further defined | 1,28,33,35 | 8 |
Salinas CA [188], 2010, US | M | 2002–2005 | SEER cancer registry | 1000 | 942 | Prostate cancer | Questionnaire | Use at least once per week for 3 months(ever use) | 1,11,42 | 7 |
Harris RE [189], 2007, US | M | 1999–2005 | CHRI | 24 | 39 | Prostate cancer | Medical-record | At least two times per week for 2 years or more | 1,3,5,6,10 | 5 |
Bosetti C [190], 2006, Italy | M | 1991–2002 | Population from the greater Milan area, the provinces of Pordenone, Gorizia, Latina and the urban area of Naples | 1261 | 1131 | Prostate cancer | Standard questionnaire | Use at least once a week for more than 6 months (regular) | 1,4,5,34 | 5 |
Dasgupta K [191], 2006, Canada | M | 1999–2002 | RAMQ | 2025 | 2150 | Prostate cancer | Prescription database | Did not receive any prescription for aspirin (nonuser) | 1,43 | 6 |
Liu X [192], 2006, US | M | 2001–2004 | Population from Cleveland, Ohio | 471 | 468 | Prostate cancer | Personal interview | Use at least twice a week for more than a month(any use) | 1,11,44 | 5 |
Menezes RJ [193], 2006, US | M | 1982–1998 | RPCI | 1029 | 1029 | Prostate cancer | Questionnaire | Use at least once a week for at least 6 months (regular) | 1,5,10 | 5 |
Perron L [194], 2003, Canada | M | 1993–1995 | RAMQ | 2221 | 11,105 | Prostate cancer | Prescription database | Ever use aspirin- not further defined | 1,50 | 6 |
Norrish AE [195], 1998, New Zealand | M | 1996–1997 | Auckland Prostate Study | 317 | 480 | Prostate cancer | Questionnaire | At least once per week(regular) | 1,50,51,52,53 | 7 |
Neugut AI [80], 1998, US | M | 1989–1992 | Columbia-Prebyterian Medical Center | 319 | 189 | Prostate cancer | Medical record | Use aspirin-not further defined | 1,4,5 | 6 |
Cohort studies | ||||||||||
Cao Y [8], 2016, US | M | 1980–2010 1986–2012 | NHS and HPFS | 1019 | 135,965 | Prostate cancer | Questionnaire | Use at least 2 times per week(regular) | 3,5,6,7,8,9,10,11,12,18,19,20,21,22,23,24,25,70 | 9 |
Lapi F [196], 2016, Italya | M | 2002–2013 | HSD | 187 | 13,453 | Prostate Cancer | Prescription database | Use low-dose aspirin-not further defined | 1,3,6,9,13,14,16,28,38,54,55,56,57 | 8 |
Nordström T [197], 2015, Swedena | M | 2007–2012 | Population from Stockholm County, Sweden | 8430 | 204,241 | Prostate cancer | Swedish Prescribed Drug Register | Any dispensed prescription of the drug within 2 years before biopsy | 1,4,13,14, 58,59,60 | 5 |
Hollestein LM [91], 2014, Netherlandsa | M | 1998–2010 | PHARMO and the Eindhoven Cancer Registry | 882 | 53,679 | Prostate cancer | Prescription database | Low dose aspirin (≤ 100 mg daily)- not further defined | 1,2,26,27 | 8 |
Shebl FM [198], 2012, US | M | 1993–2001 | PLCO | 3573 | 29,450 | Prostate cancer | Questionnaire | Regular use aspirin-not further defined | 5,11,34, 42,62 | 7 |
Mahmud SM [199], 2011, Canadaa | M | 1985–2000 | Saskatchewan Ministry of Health (SH) databases and the Saskatchewan Cancer Registry (SCR). | 9007 | 35,891 | Prostate cancer | Prescription database | Had a participant ever filled a prescription of aspirin in the index class at any time during his exposure history | 28,41,42 | 6 |
Brasky TM [200], 2010, US | M | 2000–2007 | VITAL Cohort | 1547 | 34,132 | Prostate cancer | Questionnaire | Use aspirin ≥1 day/ week for ≥ 1 year(regular) | 1,4,5,9,10,11,19,30,55, 65,66,67 | 5 |
Siemes C [96], 2008, Netherland | M | 1992–2004 | The Rotterdam Study | 216 | 7621 | Prostate cancer | Questionnaire and prescriptions | The absence of a prescription for any non-aspirin or aspirin NSAID(no use) | 1,3,10,61 | 8 |
Jacobs EJ [98], 2007, US | M | 1992–2003 | Cancer Prevention Study II Nutrition Cohort | 5539 | 69,810 | Prostate cancer | Questionnaire | Use at least 30 “times” per month(daily use of adult-strength) | 1,3,4,9,10,11,18, 20,28,29,30,31 | 8 |
Platz EA [201], 2005, US | M | 1980–2004 | BLSA | 141 | 9748 | Prostate cancer | Self-reported | Had ever taken aspirin-not further defined | 1,28,45,68 | 7 |
García Rodríguez LA [44], 2004, UKa | M | 1995–2001 | GPRD | 2096 | 9579 | Prostate cancer | Prescription database | No use of aspirin at any time before the index date(nonuser) | 1,45,46,47,48,49 | 8 |
Friis S [62], 2003, Denmarka | M | 1989–1997 | Population of North Jutland County | 196 | 29,470 | Prostate cancer | Prescription database | 75–150 mg once daily(low-dose aspirin) | 1,2 | 8 |
Habel LA [202], 2002, US | M | 1964–1973 | The Kaiser Permanente Medical Care Program in Northern California | 2574 | 90,100 | Prostate cancer | Questionnaire | Use more than six aspirin per days | 1,4,11,69 | 6 |
Schreinemachers DM [63], 1994, US | M | 1971–1987 | The National Health and Examination Survey Ι | 123 | 12,668 | Prostate cancer | Self reported | Use aspirin during the 30-day period before the interview | 1,2 | 6 |
Paganini-Hill A [103], 1989, US | M | 1981–1988 | Population from Leisure World, Laguna Hills, US | 149 | 13,870 | Prostate cancer | Questionnaire | Aspirin use: none,<daily, daily | 2 | 4 |