Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies

BMC Cancer

Table 10 Characteristics of included studies- cervix uterus

Study source	Sex	Study period	Source of subjects	No of case	No of control/cohort size	Cancer site	Exposure assessment	Exposure Definition	Adjustment for covariates	Study quality
Case-control studies
Friel G [183], 2015, US	F	1982–1998	RPCI	272	1072	Cervical Cancer	Questionnaire	Use at least once a week for 6 months(regular)	1,3,4,5, 6,7,8,9,10,11,12,13	7
Cohort studies
Wilson JC [184], 2013, UK^a	F	1995–2010	CPRD	724	3479	Cervical Cancer	Prescription database	Use of aspirin - not further defined	3,14,15,16,17,18,19,20,21	7
Friis S [62], 2003, Denmark^a	F	1989–1997	Population from North Jutland County	15	29,470	Cervix uterus cancer	Prescription database	75–150 mg once daily(low-dose aspirin)	1,2	8
Schreinemachers DM [63], 1994, US	F	1971–1987	The National Health and Examination Survey Ι	29	12,668	Cervix uterus cancer	Self reported	Use aspirin during the 30-day period before the interview	1,2	6

1 = age, 2 = sex, 3 = smoking, 4 = spermicide contraceptive use, 5 = circulatory system disease, 6 = education, 7 = age at first pregnancy, 8 = menopausal status, 9 = genital tract disease, 10 = year survey completed,11 = blood and blood-forming organs disease, 12 = oral, 13 = barrier, 14 = HRT use, 15 = hormone contraceptive use, 16 = systemic steroids, 17 = DMARD use, 18 = history of cancer, 19 = years of follow-up, 20 = sexually transmitted infections, 21 = use of antiviral drugs
CPRD clinical practice research datalink, RPCI the Roswell Park Cancer Institute
^aStudy deemed to be prone to immortal time bias

ISSN: 1471-2407