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Table 10 Characteristics of included studies- cervix uterus

From: Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies

Study source Sex Study period Source of subjects No of case No of control/cohort size Cancer site Exposure assessment Exposure Definition Adjustment for covariates Study quality
Case-control studies
 Friel G [183], 2015, US F 1982–1998 RPCI 272 1072 Cervical Cancer Questionnaire Use at least once a week for 6 months(regular) 1,3,4,5, 6,7,8,9,10,11,12,13 7
Cohort studies
 Wilson JC [184], 2013, UKa F 1995–2010 CPRD 724 3479 Cervical Cancer Prescription database Use of aspirin - not further defined 3,14,15,16,17,18,19,20,21 7
 Friis S [62], 2003, Denmarka F 1989–1997 Population from North Jutland County 15 29,470 Cervix uterus cancer Prescription database 75–150 mg once daily(low-dose aspirin) 1,2 8
 Schreinemachers DM [63], 1994, US F 1971–1987 The National Health and Examination Survey Ι 29 12,668 Cervix uterus cancer Self reported Use aspirin during the 30-day period before the interview 1,2 6
  1. 1 = age, 2 = sex, 3 = smoking, 4 = spermicide contraceptive use, 5 = circulatory system disease, 6 = education, 7 = age at first pregnancy, 8 = menopausal status, 9 = genital tract disease, 10 = year survey completed,11 = blood and blood-forming organs disease, 12 = oral, 13 = barrier, 14 = HRT use, 15 = hormone contraceptive use, 16 = systemic steroids, 17 = DMARD use, 18 = history of cancer, 19 = years of follow-up, 20 = sexually transmitted infections, 21 = use of antiviral drugs
  2. CPRD clinical practice research datalink, RPCI the Roswell Park Cancer Institute
  3. aStudy deemed to be prone to immortal time bias