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Table 1 Characteristics of included studies- gastric cancer

From: Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies

Study source Sex Study period Source of subjects No of case No of control/cohort size Cancer site Exposure assessment Exposure Definition Adjustment for covariates Study quality
Case-control studies
 Iqbal U [47], 2017, China M/F 2001–2011 The Taiwan NHI database 22,574 90,296 Gastric cancer Prescription Use at least for 2 months during the 3-year period before the initial cancer diagnosis 1,2,13,14,15,16,17 7
 Wang Y [48], 2015, China M/F 2005–2010 Population from China 175 350 Gastric cancer Structured questionnaire Use at least once a week for one year (regular) 2,3,5,6,7,10,18,19,20 7
 Gong EJ [49], 2014, Korea M/F 2000–2010 Asian Medical Center 327 327 Gastric cancer Self-administered questionnaire Use of aspirin - not further defined 1,2,3,4,6,8,10,11,12,18,21,22,23, 6
 Bertuccio P [50], 2010, Italy M/F 1997–2007 Population from Italy 229 543 Gastric cancer Structured questionnaire Use at least once a week for more than 6 months (regular) 1,2,4,5,6,10,24 7
 Figueroa JD [51], 2009, US M/F 1993–1995 Population from Connecticut, New Jersey, and western Washington state 367 695 Gastric adenocarcinomas Structured interviews Use at least once per week for 6 months or more 1,2,3,10,25,26 7
 Duan L [52], 2008, US M/F 1992–1997 Los Angeles County Cencer Surveillance Program 718 1356 Gastric adenocarcinoas Structured questionnaire Use of aspirin - not further defined 1,2,3,5,10,20,25,27,28 7
 Fortuny J [53], 2007, US M/F 1980–2002 1993–2004 GHC and HFHS 496 3996 Gastric cancer Outpatient pharmacy records No prescription for aspirin (never users) 1,2,25,29,30 7
 Akre K [54], 2001, Sweden M/F 1989–1995 Population from Swedish counties 567 1165 Gastric cancer Interviews Ever use of aspirin (ever users) 1,2,9 7
 Coogan PF [55], 2000, US M/F 1977–1998 Population from Baltimore, Boston, New York, and Philadelphia 254 5952 Stomach cancer Administered questionnaires Use at least 4 days/week for at least 3 months (regular) 1,2,3,4,5,6,25,32,33,34 8
 Zaridze D [56], 1999, Russia M/F 1993–1997 Moscow City Oncology Hospital and Cancer Research Center and were Moscow City residents 448 610 Stomach cancer Self-administered questionnaire Use at least 2 days a week for 6 months or more (regular) 1,5 6
Cohort studies
 Kim YI [57], 2016, Koreaa M/F 2004–2010 KNHI database 117 11,598 Gastric cancer Prescription database Never make claims for aspirin prescription or less than 6 months of aspirin prescriptions (non-users) 1,2,20, 35 7
 Lee J [58], 2012, Korea M/F 1999–2008 Samsung Medical Center 184 347 Gastric cancer Prescription Have aspirin fill prescriptions for at least 6 months 1,2,14 6
 Abnet CC [59], 2009, US M/F 1995–2003 AARP 360 311,115 Gastric cancer Questionnaire Any use in the past 12 months 1,2,3,5,6,10,34,36,37 7
 Epplein M [60], 2009, US M/F 1993–2004 Multiethnic Cohort (Hawaii and Los Angeles, California) 643 169,292 Gastric cancer Self-administered questionnaire Use any aspirin at least 2 times a week (for 1 month or longer) 1,2,3,6,10,25 7
 Lindblad M [61], 2005, UKa M/F 1994–2001 General Practitioners Research Database 1023 1000 Gastric Cancer Prescription database Any recorded use of aspirin (ever use) 1,2,3,6,10,28, 31 8
 Friis S [62], 2003, Denmarka M/F 1989–1997 Population from North Jutland County 68 29,470 Stomach cancer Prescription database 75–150 mg once daily(low-dose aspirin) 1,2 8
 Schreinemachers DM [63], 1994, US M/F 1971–1987 The National Health and Examination Survey Ι 39 12,668 Stomach cancer Self-reported Use aspirin during the 30-day period before the interview 1,2 6
  1. 1 = age, 2 = sex, 3 = smoking, 4 = family history, 5 = educational level, 6 = alcohol intake, 7 = marriage, 8 = fat distribution, 9 = social status, 10 = BMI, 11 = total cholesterol, 12 = triglyceride, 13 = charlson comorbidity index, 14 = statin, 15 = metformin, 16 = ACE inhibitors, 17 = angiotensin II receptor blockers, 18 = helicobacter pylori, 19 = history of diabetes, 20 = resident district, 21 = percent body fat, 22 = HDL cholesterol, 23 = LDL cholesterol, 24 = period of interview, 25 = race, 26 = gastro-esopageal refiux disease, 27 = antacid use, 28 = upper gastrointestinal tract history, 29 = health plan, 30 = duration of continuous, 31 = calendar year enrollment in the health plan at the date of diagnosis, 32 = interview year, 33 = center, 34 = religion, 35 = comorbidity, 36 = total calorie, fibre and calcium intake, 37 = fruit, vegetable and/or vitamin intake, 38 = physical activity, 39 = processed meat intake
  2. AARP AARP diet and health study, GHC Group Health Cooperative, HFHS Henry Ford health system’s health alliance plan, KNHI Korean National Health Insurance database
  3. aStudy deemed to be prone to immortal time bias