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Fig. 1 | BMC Cancer

Fig. 1

From: Compound A attenuates toll-like receptor 4-mediated paclitaxel resistance in breast cancer and melanoma through suppression of IL-8

Fig. 1

Transient knockdown of TLR4 in BCA cell lines and the response to PTX. Effect of siTLR4 in (a) MDA-MB-231 and (d) MDA-MB-435 cells. The level of TLR4 detected by western blot analyses in parental and siTLR4-treated (b) MDA-MB-231 and (e) MDA-MB-435 cells treated with or without PTX. β-ACTIN was used as an internal control. The bands were quantified by ImageJ® software. The percentage of viability after exposure to PTX in parental and siTLR4-treated MDA-MB-231 (c) and MDA-MB-435 (f) cells. The percentage of viable mock cells without PTX treatment was assumed to be 100%. Bars represent mean ± SD of independent duplicate experiments. *represents p-value < 0.05

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