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Table 3 Correlation between the clinicopathological features and 3-year overall survival in combined hepatocellular cholangiocarcinoma

From: Positive expression of Midkine predicts early recurrence and poor prognosis of initially resectable combined hepatocellular cholangiocarcinoma

Variables

No. of patients

Cumulative

3- year Overall survival rate

P

HR (95% CI)

P

Age

  < 60

28

46.1%

0.962

  

60

24

41.9%

Gender

 Male

37

41.7%

0.531

  

 Female

15

58.8%

Hepatitis B

 Negative

17

15.1%

0.208

  

 Positive

35

58.8%

Hepatitis C

 Negative

36

49.4%

0.548

  

 Positive

16

29.8%

Liver cirrhosis

 No cirrhosis

14

49.9%

0.649

  

 Cirrhosis

38

45.7%

DM

 Negative

38

44.5%

0.816

  

 Positive

14

44.9%

Gall stone

 Negative

47

49.7%

0.109

  

 Positive

5

0%

CEA

  ≤ 5

45

48.6%

0.052

  

  > 5

7

0%

CA-199

  ≤ 35

36

52.6%

0.069

  

  > 35

16

24.6%

AFP

  ≤ 15

23

42.7%

0.825

  

  > 15

29

45.6%

Histology grade

 Well or Moderate

38

49.3%

0.328

  

 Poorly

14

22.4%

LVI

 Negative

33

60.8%

0.009*

  

 Positive

19

18.3%

PNI

 Negative

46

48.2%

0.060

  

 Positive

6

0%

Surgical margin

 < 10 mm

35

41.2%

0.552

  

  ≥ 10 mm

17

61.6%

T stage

 TI-II

42

56.9%

< 0.001*

  

 TIII-IV

10

0%

N stage

 Negative

49

47.7%

0.001*

  

 Positive

3

0%

AJCC staging

 I-II

40

60.4%

< 0.001*

12.784 (4.822-33.481)

< 0.001*

 III-IV

12

0%

Midkine expression

 Negative

30

54.2%

0.012*

  

 Positive

22

29.9%

  1. CI confidence interval, HR hazard ratio