Positive expression of Midkine predicts early recurrence and poor prognosis of initially resectable combined hepatocellular cholangiocarcinoma

Table 3 Correlation between the clinicopathological features and 3-year overall survival in combined hepatocellular cholangiocarcinoma

Variables	No. of patients	Cumulative 3- year Overall survival rate	P	HR (95% CI)	P
Age
< 60	28	46.1%	0.962
≧60	24	41.9%	0.962
Gender
Male	37	41.7%	0.531
Female	15	58.8%	0.531
Hepatitis B
Negative	17	15.1%	0.208
Positive	35	58.8%	0.208
Hepatitis C
Negative	36	49.4%	0.548
Positive	16	29.8%	0.548
Liver cirrhosis
No cirrhosis	14	49.9%	0.649
Cirrhosis	38	45.7%	0.649
DM
Negative	38	44.5%	0.816
Positive	14	44.9%	0.816
Gall stone
Negative	47	49.7%	0.109
Positive	5	0%	0.109
CEA
≤ 5	45	48.6%	0.052
> 5	7	0%	0.052
CA-199
≤ 35	36	52.6%	0.069
> 35	16	24.6%	0.069
AFP
≤ 15	23	42.7%	0.825
> 15	29	45.6%	0.825
Histology grade
Well or Moderate	38	49.3%	0.328
Poorly	14	22.4%	0.328
LVI
Negative	33	60.8%	0.009*
Positive	19	18.3%	0.009*
PNI
Negative	46	48.2%	0.060
Positive	6	0%	0.060
Surgical margin
< 10 mm	35	41.2%	0.552
≥ 10 mm	17	61.6%	0.552
T stage
TI-II	42	56.9%	< 0.001*
TIII-IV	10	0%	< 0.001*
N stage
Negative	49	47.7%	0.001*
Positive	3	0%	0.001*
AJCC staging
I-II	40	60.4%	< 0.001*	12.784 (4.822-33.481)	< 0.001*
III-IV	12	0%	< 0.001*	12.784 (4.822-33.481)	< 0.001*
Midkine expression
Negative	30	54.2%	0.012*
Positive	22	29.9%	0.012*

ISSN: 1471-2407