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Table 3 Correlation between the clinicopathological features and 3-year overall survival in combined hepatocellular cholangiocarcinoma

From: Positive expression of Midkine predicts early recurrence and poor prognosis of initially resectable combined hepatocellular cholangiocarcinoma

Variables No. of patients Cumulative
3- year Overall survival rate
P HR (95% CI) P
Age
  < 60 28 46.1% 0.962   
60 24 41.9%
Gender
 Male 37 41.7% 0.531   
 Female 15 58.8%
Hepatitis B
 Negative 17 15.1% 0.208   
 Positive 35 58.8%
Hepatitis C
 Negative 36 49.4% 0.548   
 Positive 16 29.8%
Liver cirrhosis
 No cirrhosis 14 49.9% 0.649   
 Cirrhosis 38 45.7%
DM
 Negative 38 44.5% 0.816   
 Positive 14 44.9%
Gall stone
 Negative 47 49.7% 0.109   
 Positive 5 0%
CEA
  ≤ 5 45 48.6% 0.052   
  > 5 7 0%
CA-199
  ≤ 35 36 52.6% 0.069   
  > 35 16 24.6%
AFP
  ≤ 15 23 42.7% 0.825   
  > 15 29 45.6%
Histology grade
 Well or Moderate 38 49.3% 0.328   
 Poorly 14 22.4%
LVI
 Negative 33 60.8% 0.009*   
 Positive 19 18.3%
PNI
 Negative 46 48.2% 0.060   
 Positive 6 0%
Surgical margin
 < 10 mm 35 41.2% 0.552   
  ≥ 10 mm 17 61.6%
T stage
 TI-II 42 56.9% < 0.001*   
 TIII-IV 10 0%
N stage
 Negative 49 47.7% 0.001*   
 Positive 3 0%
AJCC staging
 I-II 40 60.4% < 0.001* 12.784 (4.822-33.481) < 0.001*
 III-IV 12 0%
Midkine expression
 Negative 30 54.2% 0.012*   
 Positive 22 29.9%
  1. CI confidence interval, HR hazard ratio