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Table 2 Common dysregulated pathways identified by KEGG database in iPSC-CRL-1831 and CSC-DLD1

From: Microenvironment dependent gene expression signatures in reprogrammed human colon normal and cancer cell lines

Functional categories

iPSC-CRL-1831

CSC-DLD1

Common genes

p value

Genes

p value

Genes

 Cell interaction

     

  Adherens junction

5.11e-06

18

0.0014

12

6

  Tight junction

0.0001

22

0.0157

14

9

  Regulation of actin cytoskeleton

0.0013

27

0.0006

25

10

  Cell adhesion molecules (CAMs)

0.0040

18

0.0301

13

10

  Focal adhesion

0.0043

24

0.0001

26

10

  Gap junction

–

–

0.0273

10

–

  ECM-receptor interaction

–

–

0.0394

9

–

 Stemness

     

  Wnt signaling pathway

0.0003

23

8.54e-05

22

10

  TGF-β signaling pathway

0.0110

12

0.0381

9

5

  Hedgehog signaling pathway

0.0130

9

0.0156

8

4

  Notch signaling pathway

0.0365

7

0.0172

7

2

 Cancer transformation/metastasis

     

  Pathways in cancer

1.36e-09

55

4.18e-05

38

16

  P53 signaling pathway

2.65e-05

16

0.0002

13

7

  Colorectal cancer

0.0003

14

0.0103

9

3

  VEGF signaling pathway

0.0009

14

–

–

–

  MAPK signaling pathway

0.0070

29

3.80e-06

36

10

  mTOR signaling pathway

0.0088

9

–

–

–

  Apoptosis

0.0297

11

0.0113

11

5

  1. Common genes: number of common genes included in both cell lines