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Table 2 Common dysregulated pathways identified by KEGG database in iPSC-CRL-1831 and CSC-DLD1

From: Microenvironment dependent gene expression signatures in reprogrammed human colon normal and cancer cell lines

Functional categories iPSC-CRL-1831 CSC-DLD1 Common genes
p value Genes p value Genes
 Cell interaction      
  Adherens junction 5.11e-06 18 0.0014 12 6
  Tight junction 0.0001 22 0.0157 14 9
  Regulation of actin cytoskeleton 0.0013 27 0.0006 25 10
  Cell adhesion molecules (CAMs) 0.0040 18 0.0301 13 10
  Focal adhesion 0.0043 24 0.0001 26 10
  Gap junction 0.0273 10
  ECM-receptor interaction 0.0394 9
 Stemness      
  Wnt signaling pathway 0.0003 23 8.54e-05 22 10
  TGF-β signaling pathway 0.0110 12 0.0381 9 5
  Hedgehog signaling pathway 0.0130 9 0.0156 8 4
  Notch signaling pathway 0.0365 7 0.0172 7 2
 Cancer transformation/metastasis      
  Pathways in cancer 1.36e-09 55 4.18e-05 38 16
  P53 signaling pathway 2.65e-05 16 0.0002 13 7
  Colorectal cancer 0.0003 14 0.0103 9 3
  VEGF signaling pathway 0.0009 14
  MAPK signaling pathway 0.0070 29 3.80e-06 36 10
  mTOR signaling pathway 0.0088 9
  Apoptosis 0.0297 11 0.0113 11 5
  1. Common genes: number of common genes included in both cell lines