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Fig. 4 | BMC Cancer

Fig. 4

From: Microenvironment dependent gene expression signatures in reprogrammed human colon normal and cancer cell lines

Fig. 4

The interaction network of genes sets (cluster obtained by ClusterViz from GeneMANIA and visualized in Cytoscape). The interaction networks of significantly enriched and predicted genes for cell interaction (a), stemness (b), cancer transformation/metastases (c) categories. Networks 1, 3, 5 and networks 2, 4, 6 represent different categories for iPSC-CRL-1831 and CSC-DLD1, respectively. Nodes in blue are selected genes, nodes in green are GeneMania predicted genes, nodes in red represent hub genes. Totally, we identified 9 hub genes: CTNNB1, CTNNA1, CTNNA2 - catenin (cadherin-associated protein), beta1 and/or alpha1 and/or alpha2; PPP2CA - protein phosphatase 2, catalytic subunit, alpha isozymer; JUN - jun proto-oncogene; MAGI1 - membrane associated guanylate kinase, WW and PDZ domain containing 1; NCOR2 - nuclear receptor corepressor 2; CTBP2 - C-terminal binding protein 2; CACNA2D3 - calcium channel, voltage-dependent, alpha 2/delta subunit 3

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BMC Cancer

ISSN: 1471-2407

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