Table 4 Incidence of treatment-emergent drug-related adverse events by worst grade and Child-Pugh class at start of therapy
Drug-related adverse events | Child-Pugh A | Child-Pugh B | Child-Pugh C |
|---|---|---|---|
(n = 246) | (n = 48) | (n = 2) | |
Any adverse event | 67 (27) | 17 (35) | 0 (0) |
 Cardiac, general | 8 (3.3) | 1 (2.1) | 0 (0) |
 Hypertension | 7 (2.8) | 1 (2.1) | 0 (0) |
 Hypotension | 2 (0.8) | 0 (0) | 0 (0) |
 Constitutional symptoms | 2 (0.8) | 0 (0) | 0 (0) |
 Fatigue | 1 (0.4) | 0 (0) | 0 (0) |
 Fever | 1 (0.4) | 0 (0) | 0 (0) |
 Dermatology/skin | 58 (24) | 12 (25) | 0 (0) |
 Alopecia | 6 (2.4) | 2 (4.2) | 0 (0) |
 Hand-foot skin reaction | 51 (21) | 7 (15) | 0 (0) |
 Rash/desquamation | 8 (3.3) | 3 (6.3) | 0 (0) |
 Ulceration | 0 (0) | 0 (0) | 0 (0) |
 Gastrointestinal | 25 (10) | 8 (17) | 0 (0) |
 Diarrhea | 25 (10) | 7 (15) | 0 (0) |
 Nausea | 0 (0) | 1 (2.1) | 0 (0) |