High-level cytoplasmic claudin 3 expression is an independent predictor of poor survival in triple-negative breast cancer

Table 3 Significant 2-sided p-values of associations between claudin (cl) 3, 4 and 7 expression and traditional prognostic factors, EMT-regulating transcription factors and survival in univariate analysis

	Cyt cl 3	Membr cl 3	Cyt cl 4	Cyt cl 7	Membr cl 7	Membr claudin low	Cyt claudin low
T (T1 vs. T2–4)				0.0053			0.0074
N (N0 vs. N1–3)						0.013
Grade (I–II vs. III)				0.043			0.013
TNBC	0.012			0.0026	0.00023		0.0033
BLBC	0.026		0.00090	0.023			0.0050
Ki67 (0–14% vs. > 14%)					0.0042
1st metastatic site only in bone		0.032		0.016
Zeb1					0.010
Vimentin					0.042
Cytoplasmic Sip1				0.0012			0.0029
Nuclear Sip1	0.000053						0.0029
DFS	0.0009
DDFS	0.006
RFS	0.000011						0.0033
BCSS	0.001
OS	0.018

The directions of the associations are described in the Results section. Cyt, cytoplasmic; Membr, membranous; TNBC, triple-negative breast cancer; BLBC, basal-like breast cancer; DFS, disease-free survival; DDFS, distant disease-free survival; RFS, relapse-free survival; BCSS, breast cancer-specific survival; OS, overall survival

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