Table 2 Expression levels of claudins 3, 4 and 7 in the whole material, separately in TNBC and non-TNBC groups and significance in comparison of the two groups (p-value, 2-sided Pearson’s chi-square test)
Total N (%) | TNBC N (%) | Non-TNBC N (%) | p-value between TNBC and non-TNBC | |
|---|---|---|---|---|
Cytoplasmic Claudin 7 | 185 (100.0) | 115 (100.0) | 70 (100.0) | |
CL 7 cytoplasmic 0–5% | 98 (53.0) | 51 (44.3) | 47 (67.1) | 0.0026 |
CL 7 cytoplasmic 6–100% | 87 (47.0) | 64 (55.7) | 23 (32.9) | |
Membranous Claudin 7 | 185 (100.0) | 115 (100.0) | 70 (100.0) | |
CL7 membranous 0–5% | 141 (76.2) | 98 (85.2) | 43 (61.4) | 0.00023 |
CL 7 membranous 6–100% | 44 (23.8) | 17 (14.8) | 27 (38.6) | |
Cytoplasmic Claudin 4 | 191 (100.0) | 116 (100.0) | 75 (100.0) | |
CL 4 cytoplasmic 0–50% | 180 (94.2) | 109 (94.0) | 71 (94.7) | NS |
CL 4 cytoplasmic 51–100% | 11 (5.8) | 7 (6.0) | 4 (5.3) | |
Membranous Claudin 4 | 191 (100.0) | 116 (100.0) | 75 (100.0) | |
CL 4 membranous 0–50% | 73 (38.2) | 45 (38.8) | 28 (37.3) | NS |
CL 4 membranous 51–100% | 118 (61.8) | 71 (61.2) | 47 (62.7) | |
Cytoplasmic Claudin 3 | 187 (100.0) | 111 (100.0) | 76 (100.0) | |
CL 3 cytoplasmic 0–50% | 174 (93.0) | 99 (89.2) | 77 (98.7) | 0.012 |
CL 3 cytoplasmic 51–100% | 13 (7.0) | 12 (10.8) | 1 (1.3) | |
Membranous Claudin 3 | 187 (100.0) | 111 (100.0) | 76 (100.0) | |
CL 3 membranous 0–50% | 99 (52.9) | 63 (56.8) | 36 (47.4) | NS |
CL 3 membranous 51–100% | 88 (47.1) | 48 (43.2) | 40 (52.6) | |
Membranous claudin | 190 (100.0) | 114 (100.0) | 76 (100.0) | |
Low membranous expression of claudins 3, 4 and 7 | 37 (19.5) | 25 (21.9) | 12 (15.8) | NS |
High membranous expression of at least one claudin | 153 (80.5) | 89 (78.1) | 64 (84.2) | |
Cytoplasmic claudin | 174 (100.0) | 106 (100.0) | 68 (100.0) | |
Low cytoplasmic expression of claudins 3, 4 and 7 | 91 (52.3) | 46 (43.4) | 45 (66.2) | 0.0033 |
High cytoplasmic expression of at least one claudin | 83 (47.7) | 60 (56.6) | 23 (33.8) |