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Table 3 Univariate and multivariate Cox proportional hazards analysis of factors influencing 5-year overall survival for patients who underwent FOLFOX/CapeOX chemotherapy

From: Impact of timing of adjuvant chemotherapy on survival in stage III colon cancer: a population-based study

Variables

Univariate analysis

Multivariate analysis*

HR

95% CI

P

HR

95% CI

P

Gender

  

0.092

   

 Male

1

     

 Female

0.845

0.695–1.028

    

Age at diagnosis, years

  

0.003

  

0.007

 66–70

1

  

1

  

 71–75

1.122

0.872–1.443

 

1.149

0.888–1.486

 

 76–80

1.286

0.994–1.665

 

1.293

0.991–1.688

 

  > 80

1.812

1.305–2.517

 

1.816

1.285–2.566

 

Race

  

0.206

   

 White

1

     

 Black

1.028

0.719–1.469

    

 Asian

1.156

0.677–1.972

    

 Other

0.502

0.259–0.973

    

Marital status

  

0.167

   

 Single+Separated

1

     

 Married

1.036

0.696–1.543

    

 Divorced+Widowed

1.318

0.869–1.999

    

 Other

1.066

0.540–2.104

    

Residence location

  

0.329

   

 Big Metro

1

     

 Metro or Urban

1.071

0.865–1.327

    

 Less Urban or Rural

1.252

0.929–1.686

    

Median household income

  

0.007

  

0.497

 1st quartile

1

  

1

  

 2nd quartile

0.962

0.733–1.261

 

1.021

0.755–1.380

 

 3rd quartile

0.745

0.561–0.989

 

0.814

0.575–1.152

 

 4th quartile

0.620

0.465–0.826

 

0.792

0.529–1.186

 

 Unknown

0.800

0.496–1.291

 

0.947

0.514–1.743

 

Level of education

  

0.006

  

0.263

 1st quartile

1

  

1

  

 2nd quartile

1.524

1.117–2.079

 

1.371

0.979–1.920

 

 3rd quartile

1.552

1.147–2.100

 

1.379

0.960–1.982

 

 4th quartile

1.744

1.298–2.343

 

1.289

0.854–1.947

 

 Unknown

1.417

0.863–2.327

 

N/Aa

N/Aa

 

Year of diagnosis

  

0.398

   

 2001–2004

1

     

 2005–2008

0. 897

0.697–1.154

    

Primary tumor site

  

0.150

   

 right-sided colon

1

     

 left-sided colon

0.878

0.711–1.084

    

 unknown

1.602

0.824–3.114

    

Histologic grade

  

< 0.001

  

0.022

 Well

1

  

1

  

 Moderate

1.170

0.724–1.892

 

1.015

0.623–1.653

 

 Poor+Undifferentiated

1.973

1.211–3.215

 

1.407

0.856–2.315

 

 Unknown

1.376

0.598–3.165

 

0.987

0.422–2.309

 

Histologic type

  

0.008

  

0.148

 Adenocarcinoma

1

  

1

  

 Mucinous carcinoma

1.491

1.146–1.940

 

1.306

0.997–1.712

 

 Signet-ring cell carcinoma

1.467

0.728–2.959

 

1.147

0.556–2.366

 

pT category

  

< 0.001

  

< 0.001

 pT1

1

  

1

  

 pT2

1.374

0.499–3.780

 

1.472

0.531–4.080

 

 pT3

3.645

1.506–8.823

 

2.730

1.118–6.667

 

 pT4a

6.221

2.494–15.521

 

5.077

2.014–12.801

 

 pT4b

7.165

2.766–18.559

 

4.350

1.656–11.424

 

pN category

  

< 0.001

  

< 0.001

 pN1a

1

  

1

  

 pN1b

1.581

1.172–2.132

 

1.475

1.090–1.996

 

 pN2a

2.301

1.691–3.132

 

1.970

1.440–2.696

 

 pN2b

4.310

3.195–5.814

 

3.408

2.497–4.650

 

Preoperative intestinal obstruction

  

< 0.001

  

0.055

 No

1

  

1

  

 Yes

1.680

1.340–2.106

 

1.258

0.995–1.590

 

Preoperative intestinal perforation

  

0. 165

   

 No

1

     

 Yes

1.770

0.790–3.966

    

HCC risk score

  

< 0.001

  

< 0.001

 1st quartile

1

  

1

  

 2nd quartile

0.936

0.683–1.283

 

1.129

0.816–1.561

 

 3rd quartile

1.033

0.754–1.415

 

1.273

0.918–1.765

 

 4th quartile

1.994

1.469–2.705

 

2.197

1.592–3.033

 

Number of examined lymph node

  

0.382

   

  ≥ 12

1

     

  < 12

0.906

0.727–1.130

    

Postoperative radiotherapy

  

0.055

   

 No

1

     

 Yes

1.850

0.988–3.467

    

Timing to AC

  

< 0.001

  

< 0.001

  ≤ 4 weeks

1

  

1

  

 5–8 weeks

1.028

0.635–1.663

 

1.009

0.619–1.644

0.971

 9–12 weeks

1.665

1.012–2.739

 

1.640

0.990–2.717

0.055

 13–16 weeks

1.671

0.935–2.988

 

1.422

0.788–2.566

0.243

  ≥ 17 weeks

3.144

1.731–5.710

 

2.482

1.354–4.549

0.003

  1. Abbreviation FOLFOX/CapeOX 5-FU/capecitabine plus oxaliplatin, HR Hazard ratio, CI Confidence interval, HCC Hierarchical Condition Categories, AC Adjuvant chemotherapy
  2. *Only variables with a p < 0.05 in the univariate analysis were included in the multivariate analysis
  3. aunavailable because of colinearity with the variable of Median household income
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