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Table 1 Discovery (n = 13) and Validation (n = 16) datasets of patients with non-small cell lung cancer containing PD-1 clinical response and patient-specific simulation models containing PD-1 predicted response, predicted PD-L1 expression, immunosuppressive biomarker expression, and predicted dendritic cell (DC) infiltration index

From: Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy

DISCOVERY DATASET
     Immunosuppressive Biomarkers
Study ID PD-1 Clinical Response PD-1 Predicted response Score PDL1 TGFB1 IDO1 IL6 VEGFA TDO2 PGE2 IL10 LGALS9 FASLG CD47 CTLA4 PDCD1LG2 GM3 GD2 DC Index
VCMG7N NON-RESPONDER NON-RESPONDER MATCH 25.73 4.14 5.27 14.79 11.31 0.98 4.67 14.50 0.20 −5.99 3.20 10.76 1.36 25.57 25.57 17.85
L11LVL NON-RESPONDER NON-RESPONDER MATCH 18.95 −1.08 −2.33 7.89 14.14 1.38 −7.60 8.51 −0.03 −2.32 3.74 6.15 1.51 14.48 14.48 14.73
UC2LIA NON-RESPONDER NON-RESPONDER MATCH 78.62 44.67 5.44 131.81 48.07 3.35 16.14 41.95 2.68 −2.61 6.30 12.10 2.82 25.52 25.52 40.42
X0152B NON-RESPONDER NON-RESPONDER MATCH 21.87 9.51 0.84 16.17 15.78 0.23 38.50 13.54 −0.43 −7.37 7.44 12.07 1.40 −0.01 −0.01 26.80
QIA43T NON-RESPONDER NON-RESPONDER MATCH 41.42 57.12 −3.64 55.10 40.89 4.06 12.60 36.51 1.78 1.26 1.09 6.57 4.83 21.57 21.57 42.21
J0T9TJ NON-RESPONDER NON-RESPONDER MATCH 44.40 26.90 −2.55 20.21 17.96 1.44 20.71 12.71 5.92 − 0.96 2.03 2.24 14.55 14.55 2.56 16.71
3DJF3O NON-RESPONDER NON-RESPONDER MATCH 21.81 7.76 4.19 21.26 9.45 0.78 1.97 11.54 1.58 −8.74 3.34 1.97 1.72 18.63 18.63 18.29
MG6XF2 NON-RESPONDER NON-RESPONDER MATCH 11.08 7.54 1.97 81.93 25.47 −0.98 4.74 9.51 1.11 −1.15 2.01 17.50 0.86 5.92 5.92 5.31
C9TGAJ RESPONDER RESPONDER MATCH 43.42 23.05 4.64 37.16 31.76 2.75 9.86 25.25 5.24 −11.30 6.60 11.83 4.15 40.30 40.30 37.91
RDD2UW RESPONDER RESPONDER MATCH 54.86 49.36 10.35 47.04 22.34 1.97 19.41 22.51 14.47 − 0.25 3.40 2.96 4.87 29.93 29.93 32.66
L8MTGU RESPONDER RESPONDER MATCH 34.59 18.21 6.31 38.22 16.49 1.36 2.37 17.06 3.48 − 8.50 4.08 7.70 2.37 26.69 26.69 23.76
2FCOH7 RESPONDER NON-RESPONDER MISMATCH 31.78 35.02 −7.84 28.65 63.79 4.39 −32.22 23.15 8.79 −5.90 6.16 48.00 8.42 41.16 41.16 26.35
P90A0O RESPONDER RESPONDER MATCH 34.09 19.79 5.98 35.86 15.08 1.67 2.38 17.45 6.00 −7.27 4.36 3.32 2.64 29.91 29.91 28.49
   Total score 92.31                 
VALIDATION DATASET
     Immunosuppressive Biomarkers
Study ID Clinical Response Predicted response Score PDL1 TGFB1 IDO1 IL6 VEGFA TDO2 PGE2 IL10 LGALS9 FASLG CD47 CTLA4 PDCD1LG2 GM3 GD2 DC Index
195P5D NON-RESPONDER NON-RESPONDER MATCH 27.60 15.20 0.97 26.76 12.90 1.33 9.08 16.51 3.54 − 8.83 5.99 1.66 45.78 25.94 25.94 26.60
ZNT6MQ NON-RESPONDER NON-RESPONDER MATCH 76.54 31.90 −0.45 101.96 36.03 5.64 23.13 40.46 3.63 − 0.76 9.05 2.29 10.64 41.99 41.99 48.94
ZX7V33 NON-RESPONDER NON-RESPONDER MATCH 33.70 5.06 5.19 19.67 6.96 0.71 −0.39 9.31 2.49 −7.64 3.26 1.76 1.45 14.28 14.28 16.00
F3FK2W NON-RESPONDER RESPONDER MISMATCH 63.86 17.70 3.87 25.27 15.83 −3.05 5.47 19.72 −4.96 − 4.56 8.16 7.10 2.98 24.03 24.03 34.14
6QFSVV NON-RESPONDER RESPONDER MISMATCH 43.31 44.18 5.31 42.83 19.40 1.86 14.62 18.65 12.46 − 0.10 1.88 2.10 3.29 26.70 26.70 25.50
IPUAS9 NON-RESPONDER NON-RESPONDER MATCH 28.49 10.25 5.43 25.29 10.86 2.11 4.85 11.77 2.65 −1.00 3.44 7.14 1.51 13.54 13.54 15.01
GI7AGZ NON-RESPONDER RESPONDER MISMATCH 142.53 96.10 8.52 114.25 69.40 4.12 39.61 49.30 25.56 0.38 5.44 12.89 12.02 67.05 67.05 64.92
CZH5YD NON-RESPONDER NON-RESPONDER MATCH 76.21 17.60 8.11 96.00 30.61 3.17 7.75 28.32 9.96 −2.31 5.56 7.63 32.48 32.48 3.75 26.89
67K46M NON-RESPONDER NON-RESPONDER MATCH −8.33 3.34 −1.51 8.23 2.40 −0.63 2.74 2.07 −0.55 − 6.25 175.23 −0.45 0.83 3.79 3.79 4.20
3HDJMG NON-RESPONDER NON-RESPONDER MATCH 4.42 4.70 1.12 17.12 9.89 1.35 0.08 10.07 0.06 −1.35 4.61 7.45 0.17 14.17 14.17 14.40
26YMUF RESPONDER RESPONDER MATCH 29.26 9.43 5.84 24.75 10.64 2.47 5.95 13.47 2.17 −1.63 6.50 7.43 0.67 25.92 25.92 23.23
MJXYP6 RESPONDER RESPONDER MATCH 137.90 43.67 190.94 91.44 102.75 16.56 49.41 79.19 6.75 2.07 7.67 144.61 4.60 4.13 4.13 73.86
M9GYO4 RESPONDER RESPONDER MATCH 185.53 12.45 5.87 53.86 33.00 4.15 11.69 25.87 2.67 −3.16 9.09 21.21 2.04 36.09 36.09 31.90
L6ADEL RESPONDER RESPONDER MATCH 37.43 14.64 4.80 31.24 18.91 1.69 −1.21 20.73 3.77 −13.77 6.07 5.03 4.41 40.54 40.54 34.94
DFZLO2 RESPONDER RESPONDER MATCH 60.53 122.62 −0.26 51.22 57.41 3.61 229.90 62.31 8.86 −6.31 11.09 16.77 38.08 38.08 8.48 79.85
SA97V5 RESPONDER RESPONDER MATCH 67.03 12.87 15.30 56.46 21.85 −0.43 20.30 20.85 1.21 −1.90 5.28 10.32 2.79 20.96 20.96 23.81
   Total score 81.25