Fig. 4

Patient-specific simulation models were used to predict the expression of 14 immunosuppressive molecules. At step 3 of the decision tree, patients with immunosuppressive molecule predictions higher than that of PD-L1 with a margin of greater than 5.0% (bold line), were considered to be non-responders and patient-specific models with predictions lower than that of PD-L1 with a margin of greater than 5.0% were considered to be responders. Eight remaining patients were identified as responders and 4 remaining patients were identified as non-responders. Patient SA97V5 (a) had all 14 molecules below the threshold and was identified as a PD-1 drug responder. Patient QIA43T (b) had 2 molecules above the threshold and was identified as a PD-1 drug non-responder