Fig. 2

A decision tree was used to identify PD-1 drug responder status. At step 1, 9 patients with PD-L1 expression below 29.0% were identified as PD-1 drug non-responders. The remaining 16 patients (including patient SA97V5) with PD-L1 expression equal to or greater than 29.0% proceeded to step 2. At Steps 2a and 2b, 2 patients with dendritic cell infiltration index values below 20.0% were identified as non-responders and 2 patients with index values greater than 60.0% were identified as PD-1 drug responders. Twelve patients with index values greater than 20.0% (including patient SA97V5), but less than 60.0% proceeded to step 3. At Step 3, 4 patients with immunosuppressive molecule (ISM) values higher than that of their PD-L1 expression with a margin of greater than 5.0%, were identified as non-responders (Step 3a) and 8 patient-specific models with values lower than that of their PD-L1 expression with a margin of greater than 5.0% were identified as responders (Step 3b, including patient SA97V5). Mismatch patients GI7AGZ, 2FCOH7, F3FK2W were not listed