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Table 1 List of drugs from drug-screening assay with their respective solvent, and main known targets

From: A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies

Name Solvent Main Targets [65,66,67,68,69,70,71]
Dasatinib DMSO ABL, PDGFR, KIT, SRC
Erlotinib DMSO EGFR
Gefitinib DMSO EGFR
Imatinib DMSO ABL, PDGFR, KIT
Masitinib DMSO c-KIT, PDGFRα, −β, Lyn, FGFR3, FAK pathway
Nilotinib DMSO ABL, PDGFR, KIT
Toceranib DMSO VEGFR2, PDGFRβ, c-KIT
Sorafenib DMSO VEGFR2, PDGFR, KIT, FLT3, BRAF
Sunitinib DMSO VEGFR, KIT, PDGFR, RET, CSF1R, FLT3
Tozasertib DMSO SRC, GSK3, FLT3, JAK2, BCR-ABL
CCNU Ethanol Alkylation and cross-linking of DNA
Cladribine DMSO Purine analogue
Doxorubicin Saline Inhibits DNA topoisomerase II, induces DNA damage and apoptosis