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Table 1 List of drugs from drug-screening assay with their respective solvent, and main known targets

From: A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies

Name

Solvent

Main Targets [65,66,67,68,69,70,71]

Dasatinib

DMSO

ABL, PDGFR, KIT, SRC

Erlotinib

DMSO

EGFR

Gefitinib

DMSO

EGFR

Imatinib

DMSO

ABL, PDGFR, KIT

Masitinib

DMSO

c-KIT, PDGFRα, −β, Lyn, FGFR3, FAK pathway

Nilotinib

DMSO

ABL, PDGFR, KIT

Toceranib

DMSO

VEGFR2, PDGFRβ, c-KIT

Sorafenib

DMSO

VEGFR2, PDGFR, KIT, FLT3, BRAF

Sunitinib

DMSO

VEGFR, KIT, PDGFR, RET, CSF1R, FLT3

Tozasertib

DMSO

SRC, GSK3, FLT3, JAK2, BCR-ABL

CCNU

Ethanol

Alkylation and cross-linking of DNA

Cladribine

DMSO

Purine analogue

Doxorubicin

Saline

Inhibits DNA topoisomerase II, induces DNA damage and apoptosis