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Fig. 3 | BMC Cancer

Fig. 3

From: Glycolysis is essential for chemoresistance induced by transient receptor potential channel C5 in colorectal cancer

Fig. 3

Administration of 3-BP or 2DG caused a remarkable ATP production decrease (a) and cleaved Caspase-3 increasement (b) in HCT-8/5-Fu cells, while caused no obvious change to HCT-8 cells (a, b) (n = 4, *p < 0.05, one-way ANOVA). The elevated cleaved Caspase-3 induced by 2DG decreased dramatically with the administration of BAPTA-AM (b). (n = 4, *p < 0.05, one-way ANOVA). (c) Administration of 3-BP or 2DG caused increasement of [Ca2+] i level in HCT-8/5-Fu cells, while caused no obvious change to HCT-8 cells (n = 4, *p < 0.05, one-way ANOVA). Scale bars, 20 μm. d The apoptotic cells rate in HCT-8/5-Fu cells increased dramatically after treated with 2DG. The elevated apoptotic cells rate induced by 2DG decreased dramatically with the administration of BAPTA-AM (n = 4)

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