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Table 2 Neuropsychological test battery and patient-reported outcomes (PROs)

From: A randomised trial to compare cognitive outcome after gamma knife radiosurgery versus whole brain radiation therapy in patients with multiple brain metastases: research protocol CAR-study B

Cognitive Domain Cognitive Test
Verbal memory Hopkins Verbal Learning Test-Revised (HVLT-R)
Cognitive flexibility Trail Making Test B (TMT B)
Word Fluency Controlled Oral Word Association (COWA)
Working memory Wechsler Adult Intelligence Scale - Digit Span
Processing speed Wechsler Adult Intelligence Scale - Digit Symbol
Motor dexterity Grooved Pegboard (GP)
Patient Reported Outcomes Questionnaire
Quality of life Functional Assessment of Cancer Therapy-Brain (FACT-Br)a
• Physical well-being (PWB)
• Functional well-being (FWB)
• Social well-being (SWB)
• Emotional well-being (EWB)
• Brain Cancer Subscale (BRCS)
Fatigue Multidimensional Fatigue Inventory (MFI)a
• General fatigue
• Reduced motivation
• Physical fatigue
• Mental fatigue
• Reduced activity
Anxiety and depression Hospital Anxiety and Depression Scale (HADS)b
• Anxiety
• Depression
  1. aPublished normative data of FACT-Br and MFI are used for the interpretation of quality of life and fatigue scores [55, 56]
  2. bA cut-off point ≥8 is used to indicate symptoms of depression or anxiety [57]