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Table 2 Neuropsychological test battery and patient-reported outcomes (PROs)

From: A randomised trial to compare cognitive outcome after gamma knife radiosurgery versus whole brain radiation therapy in patients with multiple brain metastases: research protocol CAR-study B

Cognitive Domain

Cognitive Test

Verbal memory

Hopkins Verbal Learning Test-Revised (HVLT-R)

Cognitive flexibility

Trail Making Test B (TMT B)

Word Fluency

Controlled Oral Word Association (COWA)

Working memory

Wechsler Adult Intelligence Scale - Digit Span

Processing speed

Wechsler Adult Intelligence Scale - Digit Symbol

Motor dexterity

Grooved Pegboard (GP)

Patient Reported Outcomes

Questionnaire

Quality of life

Functional Assessment of Cancer Therapy-Brain (FACT-Br)a

• Physical well-being (PWB)

• Functional well-being (FWB)

• Social well-being (SWB)

• Emotional well-being (EWB)

• Brain Cancer Subscale (BRCS)

Fatigue

Multidimensional Fatigue Inventory (MFI)a

• General fatigue

• Reduced motivation

• Physical fatigue

• Mental fatigue

• Reduced activity

Anxiety and depression

Hospital Anxiety and Depression Scale (HADS)b

• Anxiety

• Depression

  1. aPublished normative data of FACT-Br and MFI are used for the interpretation of quality of life and fatigue scores [55, 56]
  2. bA cut-off point ≥8 is used to indicate symptoms of depression or anxiety [57]