Table 1 Selected pathway categories associated with chemoradiation resistance by pathway enrichment analysis on genes with high expression variance

Cell cycle

62

MAPK signaling

87

p53 signaling

39

WNT signaling

48

Glutathione metabolism

23

TGF- β signaling

30

Insulin signaling

40

ErbB signaling

29

Phosphatidylinositol signaling

25

Mismatch repair

12

Inositol phosphate metabolism

20

JAK-STAT signaling

22

Apoptosis

25

VEGF signaling

22

Nucleotide excision repair

15