Fig. 8

An illustration of miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry. a The decreased expression of miR-375 due to DNA hypermethylation results in the high expression of HOXB3, contributing to cell proliferation and colony formation through increasing the expression of CDCA3. Moreover, HOXB3 enhances and recruits DNMT3B to bind in pre-miR-375 promoter, leading to further DNA hypermethylation and subsequent downregulation of miR-375 in AML cells, in turn