From: High-dose thiotepa-related neurotoxicity and the role of tramadol in children
 | Patients (N = 251) | |||||
---|---|---|---|---|---|---|
Symptoms | n | NCI CTCAE grade | ||||
1 | 2 | 3 | 4 | 5 | ||
Headache, dizziness, confusion | 48 (15.6%) | 23 (47.9%) | 22 (45.8%) | 3 (6.3%) | Â | Â |
Blurred vision | 3 (1.0%) | 3 (100%) | Â | Â | Â | Â |
Tremor | 8 (2.6%) | 3 (37.5%) | 4 (50%) | 1 (12.5%) | Â | Â |
Neuralgia | 2 (0.7%) | 1 (50%) | 1 (50%) | Â | Â | Â |
Seizure | 6 (2.0%) | 2 (33.3%) | 2 (33.3%) | 1 (16.7%) | 1 (16.7%) | Â |
Pyramidal tract syndrome | 1 (0.3%) | Â | 1 (100%) | Â | Â | Â |
Cerebellar syndrome | 3 (1.0%) | Â | 2 (66.7%) | 1 (33.3%) | Â | Â |
Opsoclonus-myoclonus syndrome | 1 (0.3%) | Â | 1 (100%) | Â | Â | Â |
Coma | 1 (0.3%) | Â | 1 (100%) | Â | Â | Â |