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Table 2 Description of neurological adverse events (NAE)

From: High-dose thiotepa-related neurotoxicity and the role of tramadol in children

  Patients (N = 251)
Symptoms n NCI CTCAE grade
1 2 3 4 5
Headache, dizziness, confusion 48 (15.6%) 23 (47.9%) 22 (45.8%) 3 (6.3%)   
Blurred vision 3 (1.0%) 3 (100%)     
Tremor 8 (2.6%) 3 (37.5%) 4 (50%) 1 (12.5%)   
Neuralgia 2 (0.7%) 1 (50%) 1 (50%)    
Seizure 6 (2.0%) 2 (33.3%) 2 (33.3%) 1 (16.7%) 1 (16.7%)  
Pyramidal tract syndrome 1 (0.3%)   1 (100%)    
Cerebellar syndrome 3 (1.0%)   2 (66.7%) 1 (33.3%)   
Opsoclonus-myoclonus syndrome 1 (0.3%)   1 (100%)    
Coma 1 (0.3%)   1 (100%)