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Table 4 Assessment of interaction between serum CRP concentration and drinking status in global methylation levels in the MTHFR CT/TT group

From: Correlation between global methylation level of peripheral blood leukocytes and serum C reactive protein level modified by MTHFR polymorphism: a cross-sectional study

     

95% confidence interval

 

95% confidence interval

 

MTHFR (rs1801133)

Drinking status

CRP (mg/dL)

N

Estimated mean methylation (%)a

Lower

Upper

βab

Lower

Upper

P value for trenda

CT/TT

Never

0.002–0.011

43

69.5

67.9

71.0

    
  

0.012–0.023

33

70.5

68.9

72.2

    
  

0.024–0.048

43

71.2

69.7

72.7

    
  

0.049–0.491

45

70.6

69.0

72.1

    
       

0.41

−0.07

0.90

0.094

  

Log-transformed CRP

    

0.28

−0.25

0.81

0.307

 

Former/Current

0.002–0.011

30

70.4

68.9

71.9

    
  

0.012–0.023

26

70.3

68.6

72.0

    
  

0.024–0.048

20

71.2

69.3

73.1

    
  

0.049–0.491

24

72.8

71.1

74.6

    
       

0.83

0.23

1.44

0.007

  

Log-transformed CRP

    

0.88

0.26

1.50

0.006

  1. aAdjusted by age, BMI, smoking (never, former, current), exercise (none/week, 1–2 times/week, ≥3 times/week), folate intake (quartiles). Estimates were calculated with average values of continuous variables
  2. bAverage relative methylation difference per 1-category increase (included as continuous variable)