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Table 4 Assessment of interaction between serum CRP concentration and drinking status in global methylation levels in the MTHFR CT/TT group

From: Correlation between global methylation level of peripheral blood leukocytes and serum C reactive protein level modified by MTHFR polymorphism: a cross-sectional study

      95% confidence interval   95% confidence interval  
MTHFR (rs1801133) Drinking status CRP (mg/dL) N Estimated mean methylation (%)a Lower Upper βab Lower Upper P value for trenda
CT/TT Never 0.002–0.011 43 69.5 67.9 71.0     
   0.012–0.023 33 70.5 68.9 72.2     
   0.024–0.048 43 71.2 69.7 72.7     
   0.049–0.491 45 70.6 69.0 72.1     
        0.41 −0.07 0.90 0.094
   Log-transformed CRP      0.28 −0.25 0.81 0.307
  Former/Current 0.002–0.011 30 70.4 68.9 71.9     
   0.012–0.023 26 70.3 68.6 72.0     
   0.024–0.048 20 71.2 69.3 73.1     
   0.049–0.491 24 72.8 71.1 74.6     
        0.83 0.23 1.44 0.007
   Log-transformed CRP      0.88 0.26 1.50 0.006
  1. aAdjusted by age, BMI, smoking (never, former, current), exercise (none/week, 1–2 times/week, ≥3 times/week), folate intake (quartiles). Estimates were calculated with average values of continuous variables
  2. bAverage relative methylation difference per 1-category increase (included as continuous variable)