Correlation between global methylation level of peripheral blood leukocytes and serum C reactive protein level modified by MTHFR polymorphism: a cross-sectional study

Table 3 Adjusted estimates for mean methylation level stratified by quartile of serum CRP concentration

				95% confidence interval
MTHFR (rs1801133)	CRP (mg/dL)	N	Estimated mean methylation (%)^a	Lower	Upper
CT/TT	0.002–0.011	73	69.8	68.7	71.0
	0.012–0.023	59	70.5	69.2	71.7
	0.024–0.048	63	71.4	70.1	72.7
	0.049–0.491	69	71.6	70.4	72.8
CC	0.002–0.011	27	70.4	68.9	72.0
	0.012–0.023	30	71.3	69.8	72.8
	0.024–0.048	29	71.3	69.8	72.8
	0.049–0.491	23	70.1	68.4	71.8

^aAdjusted by age, BMI, smoking (never, former, current), exercise (none/week, 1–2 times/week, ≥3 times/week), drinking (non-drinker, sometimes, < 150 g/week, ≥150 g/week), and folate intake (quartile). Estimates were calculated with average values of continuous variables

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