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Fig. 2 | BMC Cancer

Fig. 2

From: Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells

Fig. 2

Effects of plocabulin on microtubule dynamics in HUVEC cells. a EB3-GFP maximum intensity projection for two minutes acquisition with two frames/s in each condition; EB3-GFP was transfected into HUVEC cells as describe in material and methods. b Representative kymographs of EB3 dynamics for each condition. Horizontal and vertical bars represent 1 um and 10 s respectively. c Histograms representing the mean velocity (μm/min) and distance of growth events (μm), as well as the mean catastrophe frequency (min− 1) in each condition. Data are shown as mean ± SD. Comparisons between different samples were analyzed by Student’s t test. Differences were considered significant at ***P < 0.001

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