Skip to main content
Fig. 3 | BMC Cancer

Fig. 3

From: The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1)

Fig. 3

Downstream effectors – Schematic display of UGCG regulated processes in the context of multidrug resistance. a UGCG mRNA inhibition leads to induction of apoptotic processes and prevents multidrug resistance development. b UGCG activity derived GSLs such as gangliosides regulate MDR1 promoter activity. UGCG = UDP-glucose ceramide glycosyltransferase, ERK = extracellular-signal regulated kinase, Bcl-2 = B-cell lymphoma 2, Bcl-xL = B-cell lymphoma-extra large, NFκB = nuclear factor (NF) κB, cSrc = tyrosine kinase, Gb3 = Globotriasoylceramide, MDR1 = multidrug resistance protein 1

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us