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Table 3 Stratification analysis of the NBS1 rs2735383 genotypes by selected variables in laryngeal carcinoma cases and controls

From: NBS1 rs2735383 polymorphism is associated with an increased risk of laryngeal carcinoma

  cases(n = 342) controls (n = 345) Adjusted OR (95%CI)a P interaction b
GG GC + CC GG GC + CC GC + CC vs GG
N (%) N (%) N (%) N (%)
Age
  ≤ 60 49 (14.327) 113 (33.041) 61 (17.681) 109 (31.594) 1.306 (0.811–2.106) 0.080
 >60 42 (12.281) 138 (40.351) 53 (15.362) 122 (35.363) 1.496 (0.919–2.436)  
Sex
 Male 87 (25.439) 246 (71.930) 113 (32.754) 221 (64.058) 1.505 (1.066–2.126) 0.762
 Female 4 (1.170) 5 (1.461) 1 (0.290) 10 (2.898) 0.127 (0.010–1.549)  
Ethnicity
 Han 62(18.129) 169(49.415) 81(23.478) 157(45.507) 1.439(0.954–2.169) 0.526
 Zhuang 29(8.480) 82(23.977) 33(9.565) 74(21.449) 1.394(0.755–2.573)  
Smoking status
 Ever 62 (18.129) 161 (47.076) 73 (21.159) 123 (35.652) 1.602 (1.023–2.510) 0.152
 Never 29 (8.480) 90 (26.316) 41 (11.884) 108 (31.304) 1.191 (0.681–2.083)  
Drinking status
 Ever 53 (15.497) 123 (35.965) 33 (9.565) 67 (19.420) 1.225 (0.703–2.133) 0.907
 Never 38 (11.111) 128 (37.427) 81 (23.478) 164 (47.536) 1.594 (0.985–2.514)  
  1. aORs were adjusted for age, sex, smoking status, drinking status
  2. bP value of a test the multiplicative interaction between rs2735383 and selected variables on cancer risk were calculated using logistic regression models