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Table 3 Stratification analysis of the NBS1 rs2735383 genotypes by selected variables in laryngeal carcinoma cases and controls

From: NBS1 rs2735383 polymorphism is associated with an increased risk of laryngeal carcinoma

 

cases(n = 342)

controls (n = 345)

Adjusted OR (95%CI)a

P interaction b

GG

GC + CC

GG

GC + CC

GC + CC vs GG

N (%)

N (%)

N (%)

N (%)

Age

  ≤ 60

49 (14.327)

113 (33.041)

61 (17.681)

109 (31.594)

1.306 (0.811–2.106)

0.080

 >60

42 (12.281)

138 (40.351)

53 (15.362)

122 (35.363)

1.496 (0.919–2.436)

 

Sex

 Male

87 (25.439)

246 (71.930)

113 (32.754)

221 (64.058)

1.505 (1.066–2.126)

0.762

 Female

4 (1.170)

5 (1.461)

1 (0.290)

10 (2.898)

0.127 (0.010–1.549)

 

Ethnicity

 Han

62(18.129)

169(49.415)

81(23.478)

157(45.507)

1.439(0.954–2.169)

0.526

 Zhuang

29(8.480)

82(23.977)

33(9.565)

74(21.449)

1.394(0.755–2.573)

 

Smoking status

 Ever

62 (18.129)

161 (47.076)

73 (21.159)

123 (35.652)

1.602 (1.023–2.510)

0.152

 Never

29 (8.480)

90 (26.316)

41 (11.884)

108 (31.304)

1.191 (0.681–2.083)

 

Drinking status

 Ever

53 (15.497)

123 (35.965)

33 (9.565)

67 (19.420)

1.225 (0.703–2.133)

0.907

 Never

38 (11.111)

128 (37.427)

81 (23.478)

164 (47.536)

1.594 (0.985–2.514)

 
  1. aORs were adjusted for age, sex, smoking status, drinking status
  2. bP value of a test the multiplicative interaction between rs2735383 and selected variables on cancer risk were calculated using logistic regression models