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Table 2 Frequency distribution of genotypes in NBS1 and results of logistic regression analysis for their associations with laryngeal carcinoma risk

From: NBS1 rs2735383 polymorphism is associated with an increased risk of laryngeal carcinoma

Genotypes cases controlsa P b Crude OR (95%CI) Adjusted OR (95%CI)C
N(%) N(%)
Total no. of subjects 342 345    
rs1805794(G > C)
GG 105 (30.702) 111 (32.174) 0.917 1.000 (ref) 1.000 (ref)
GC 185 (54.094) 183 (53.043)   1.069 (0.764–1.496) 1.074 (0.759–1.518)
CC 52 (15.205) 51 (14.783)   1.078 (0.674–1.724) 1.100 (0.678–1.787)
Trend test P value     0.707 0.660
GC + CC 237 (69.298) 234 (67.826)   1.071 (0.776–1.478) 1.079 (0.774–1.505)
rs2735383(G > C)
GG 91 (26.608) 114 (33.043) 0.019 1.000 (ref) 1.000 (ref)
GC 161 (47.076) 169 (48.986)   1.193 (0.841–1.694) 1.236(0.861–1.775)
CC 90 (26.316) 62 (17.971)   1.819 (1.189–2.781) 1.884 (1.215–2.921)
Trend test P value     0.007 0.005
GC + CC 251 (73.392) 231 (66.957)   1.361 (0.980–1.890) 1.410(1.004–1.980)
  1. aThe observed genotype frequencies of the two SNPs among the control subjects were all in agreement with the Hardy-Weinberg equilibrium(P > 0.05 for all)
  2. bA χ2 test for differences in distribution of genotype frequencies between cases and controls
  3. cAdjusted in a unconditional logistic regression model that included age, sex, smoking status and drinking status