Table 2 Frequency distribution of genotypes in NBS1 and results of logistic regression analysis for their associations with laryngeal carcinoma risk
From: NBS1 rs2735383 polymorphism is associated with an increased risk of laryngeal carcinoma
| Genotypes | cases | controlsa | P b | Crude OR (95%CI) | Adjusted OR (95%CI)C |
|---|---|---|---|---|---|
| N(%) | N(%) | ||||
| Total no. of subjects | 342 | 345 | |||
| rs1805794(G > C) | |||||
| GG | 105 (30.702) | 111 (32.174) | 0.917 | 1.000 (ref) | 1.000 (ref) |
| GC | 185 (54.094) | 183 (53.043) | 1.069 (0.764–1.496) | 1.074 (0.759–1.518) | |
| CC | 52 (15.205) | 51 (14.783) | 1.078 (0.674–1.724) | 1.100 (0.678–1.787) | |
| Trend test P value | 0.707 | 0.660 | |||
| GC + CC | 237 (69.298) | 234 (67.826) | 1.071 (0.776–1.478) | 1.079 (0.774–1.505) | |
| rs2735383(G > C) | |||||
| GG | 91 (26.608) | 114 (33.043) | 0.019 | 1.000 (ref) | 1.000 (ref) |
| GC | 161 (47.076) | 169 (48.986) | 1.193 (0.841–1.694) | 1.236(0.861–1.775) | |
| CC | 90 (26.316) | 62 (17.971) | 1.819 (1.189–2.781) | 1.884 (1.215–2.921) | |
| Trend test P value | 0.007 | 0.005 | |||
| GC + CC | 251 (73.392) | 231 (66.957) | 1.361 (0.980–1.890) | 1.410(1.004–1.980) | |