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Table 2 Frequency distribution of genotypes in NBS1 and results of logistic regression analysis for their associations with laryngeal carcinoma risk

From: NBS1 rs2735383 polymorphism is associated with an increased risk of laryngeal carcinoma

Genotypes

cases

controlsa

P b

Crude OR (95%CI)

Adjusted OR (95%CI)C

N(%)

N(%)

Total no. of subjects

342

345

   

rs1805794(G > C)

GG

105 (30.702)

111 (32.174)

0.917

1.000 (ref)

1.000 (ref)

GC

185 (54.094)

183 (53.043)

 

1.069 (0.764–1.496)

1.074 (0.759–1.518)

CC

52 (15.205)

51 (14.783)

 

1.078 (0.674–1.724)

1.100 (0.678–1.787)

Trend test P value

   

0.707

0.660

GC + CC

237 (69.298)

234 (67.826)

 

1.071 (0.776–1.478)

1.079 (0.774–1.505)

rs2735383(G > C)

GG

91 (26.608)

114 (33.043)

0.019

1.000 (ref)

1.000 (ref)

GC

161 (47.076)

169 (48.986)

 

1.193 (0.841–1.694)

1.236(0.861–1.775)

CC

90 (26.316)

62 (17.971)

 

1.819 (1.189–2.781)

1.884 (1.215–2.921)

Trend test P value

   

0.007

0.005

GC + CC

251 (73.392)

231 (66.957)

 

1.361 (0.980–1.890)

1.410(1.004–1.980)

  1. aThe observed genotype frequencies of the two SNPs among the control subjects were all in agreement with the Hardy-Weinberg equilibrium(P > 0.05 for all)
  2. bA χ2 test for differences in distribution of genotype frequencies between cases and controls
  3. cAdjusted in a unconditional logistic regression model that included age, sex, smoking status and drinking status