The association of diabetes mellitus and insulin treatment with expression of insulin-related proteins in breast tumors

Table 1 Odds ratios for tumor protein expression status of women with diabetes compared to women without diabetes

Women with breast cancer
	Independent variable of exposure
	Diabetes vs. No Diabetes		Diabetes vs. No Diabetes
Dependent variable^a	crude OR (95% CI)	P	adjusted OR^b (95% CI)	P
p-ER +	0.84 (0.51–1.37)	0.48	1.03 (0.61–1.73)	0.92
EGFR +	1.44 (0.59–3.52)	0.43	1.72 (0.68–4.33)	0.25
p-ERK 1/2 +	0.84 (0.52–1.37)	0.48	0.84 (0.51–1.40)	0.51
p-mTOR +	0.81 (0.49–1.33)	0.40	0.88 (0.52–1.49)	0.64
IGF1R +	0.90 (0.52–1.56)	0.70	0.94 (0.53–1.65)	0.82

^aLogistic regression for tumor IHC marker as the dependent variable, with a negative staining of the tumor marker as reference category. ^bAdjusted for menopause (pre/post) at breast cancer diagnosis and BMI closest measure prior to breast cancer diagnosis (continuous). Women with diabetes were matched on age at breast cancer diagnosis to women without diabetes. p-ER Phosphorylated estrogen receptor, EGFR Epidermal growth = factor receptor, p-ERK Phosphorylated extracellular signal-regulated kinase, p-mTOR Phosphorylated mechanistic target of rapamycin, IGF1R Insulin growth factor 1 receptor, OR Odds Ratio, CI Confidence Interval

ISSN: 1471-2407