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Table 1 Odds ratios for tumor protein expression status of women with diabetes compared to women without diabetes

From: The association of diabetes mellitus and insulin treatment with expression of insulin-related proteins in breast tumors

Women with breast cancer
  Independent variable of exposure
  Diabetes vs. No Diabetes Diabetes vs. No Diabetes
Dependent variablea crude OR (95% CI) P adjusted ORb (95% CI) P
p-ER + 0.84 (0.51–1.37) 0.48 1.03 (0.61–1.73) 0.92
EGFR + 1.44 (0.59–3.52) 0.43 1.72 (0.68–4.33) 0.25
p-ERK 1/2 + 0.84 (0.52–1.37) 0.48 0.84 (0.51–1.40) 0.51
p-mTOR + 0.81 (0.49–1.33) 0.40 0.88 (0.52–1.49) 0.64
IGF1R + 0.90 (0.52–1.56) 0.70 0.94 (0.53–1.65) 0.82
  1. aLogistic regression for tumor IHC marker as the dependent variable, with a negative staining of the tumor marker as reference category. bAdjusted for menopause (pre/post) at breast cancer diagnosis and BMI closest measure prior to breast cancer diagnosis (continuous). Women with diabetes were matched on age at breast cancer diagnosis to women without diabetes. p-ER Phosphorylated estrogen receptor, EGFR Epidermal growth = factor receptor, p-ERK Phosphorylated extracellular signal-regulated kinase, p-mTOR Phosphorylated mechanistic target of rapamycin, IGF1R Insulin growth factor 1 receptor, OR Odds Ratio, CI Confidence Interval