Fig. 15From: Exploration for novel inhibitors showing back-to-front approach against VEGFR-2 kinase domain (4AG8) employing molecular docking mechanism and molecular dynamics simulationsBack-to-front pattern of binding. a) Depiction of the presence of Hit in the active site pocket in back-to-front fashion. A clear enlarged cavity is represented in b and c. The ligand was found to be seated firmly with Cys919 from the top and is sandwiched with Glu885 and Asp1046Back to article page